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- 抗原 See all MSH2 抗体
- MSH2 (Mismatch Repair Protein 2 (MSH2))
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This MSH2 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- 交叉反应
- 人
- 纯化方法
- Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
- 免疫原
- Purified His-tagged MSH2 protein was used to produced this monoclonal antibody.
- 克隆位点
- 4C2
- 亚型
- IgG1
- Top Product
- Discover our top product MSH2 Primary Antibody
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anti-Mismatch Repair Protein 2 (MSH2) (AA 327-427) antibody
MSH2 适用: 人 WB, IHC, FACS, StM 宿主: 小鼠 Monoclonal MSH2-2622 unconjugated
anti-Mismatch Repair Protein 2 (MSH2) (AA 1-300) antibodyMSH2 适用: 人 WB, IF, IP 宿主: 兔 Polyclonal unconjugated
anti-Mismatch Repair Protein 2 (MSH2) (AA 442-586) antibodyMSH2 适用: 人, 小鼠 WB, ELISA, IHC, FACS, ICC 宿主: 小鼠 Monoclonal 2E2C7 unconjugated
anti-Mismatch Repair Protein 2 (MSH2) (AA 1-934) antibodyMSH2 适用: 人 WB, IF, PLA 宿主: 兔 Polyclonal unconjugated
anti-Mismatch Repair Protein 2 (MSH2) (AA 337-583) antibodyMSH2 适用: 人, 小鼠, 大鼠 WB, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-Mismatch Repair Protein 2 (MSH2) (AA 835-934) antibodyMSH2 适用: 人 WB, ELISA, PLA 宿主: 小鼠 Monoclonal 4B2 unconjugated
anti-Mismatch Repair Protein 2 (MSH2) (AA 224-313) antibodyMSH2 适用: 人 IHC, StM 宿主: 小鼠 Monoclonal SYP-3551 unconjugated
anti-Mismatch Repair Protein 2 (MSH2) (AA 442-586) antibodyMSH2 适用: 人 WB, ELISA, FACS 宿主: 小鼠 Monoclonal 4F10D6 unconjugated
anti-Mismatch Repair Protein 2 (MSH2) (AA 637-665) antibodyMSH2 适用: 人 WB, ELISA, IF, FACS 宿主: 兔 Polyclonal unconjugated
anti-Mismatch Repair Protein 2 (MSH2) (AA 2-254) antibodyMSH2 适用: 人 WB, ELISA, IHC, IP 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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WB 1:300-5000
FCM 1:20-100
IF() - 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 0.5 μg/μL
- 缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20°C for 12 months.
- 有效期
- 12 months
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- 抗原
- MSH2 (Mismatch Repair Protein 2 (MSH2))
- 别名
- MSH2 (MSH2 产品)
- 别名
- COCA1 antibody, FCC1 antibody, HNPCC antibody, HNPCC1 antibody, LCFS2 antibody, AI788990 antibody, wu:fc06b02 antibody, wu:fc13e09 antibody, zgc:55333 antibody, ATMSH2 antibody, MUTS homolog 2 antibody, msh2 antibody, mutS homolog 2 antibody, mutS homolog 2 (E. coli) antibody, MUTS homolog 2 antibody, mutS homolog 2 L homeolog antibody, MutS protein homolog 2 antibody, MSH2 antibody, Msh2 antibody, msh2 antibody, msh2.L antibody
- 背景
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Synonyms: FCC1, COCA1, HNPCC, LCFS2, HNPCC1, DNA mismatch repair protein Msh2, hMSH2, MutS protein homolog 2, MSH2
Background: Component of the post-replicative DNA mismatch repair system (MMR). Forms two different heterodimers: MutS alpha (MSH2-MSH6 heterodimer) and MutS beta (MSH2-MSH3 heterodimer) which binds to DNA mismatches thereby initiating DNA repair. When bound, heterodimers bend the DNA helix and shields approximately 20 base pairs. MutS alpha recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. MutS beta recognizes larger insertion-deletion loops up to 13 nucleotides long. After mismatch binding, MutS alpha or beta forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions. The ATPase activity associated with MutS alpha regulates binding similar to a molecular switch: mismatched DNA provokes ADP-->ATP exchange, resulting in a discernible conformational transition that converts MutS alpha into a sliding clamp capable of hydrolysis-independent diffusion along the DNA backbone. This transition is crucial for mismatch repair. MutS alpha may also play a role in DNA homologous recombination repair. In melanocytes may modulate both UV-B-induced cell cycle regulation and apoptosis.
- 基因ID
- 4436
- UniProt
- P43246
- 途径
- DNA Damage Repair, Production of Molecular Mediator of Immune Response
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