MSH2 抗体 (AA 327-427)
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北京 101111
Quick Overview for MSH2 抗体 (AA 327-427) (ABIN6940081)
抗原
See all MSH2 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 327-427
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原理
- MSH2 (DNA Mismatch Repair Marker) Antibody
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特异性
- Mutations in DNA mismatch repair genes are associated with hereditary nonpolyposis colorectal cancer (HNPCC). Initially, inherited mutations in the MSH2 and MLH1 homologs of the bacterial DNA mismatch repair genes MutS and MutL were found at high frequency in HNPCC and were shown to be associated with microsatellite instability. The demonstration that 10 to 45 % of pancreatic, gastric, breast, ovarian and small cell lung cancers also display microsatellite instability has been interpreted to suggest that DNA mismatch repair is not restricted to HNPCC tumors but is a common feature in tumor initiation or progression.
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纯化方法
- 200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G.
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免疫原
- Recombinant fragment (around aa 327-427) of human MSH2 protein (exact sequence is proprietary)
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亚型
- IgG1, kappa
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anti-Mismatch Repair Protein 2 (MSH2) (AA 1-300) antibody
MSH2 适用: 人 WB, IF, IP 宿主: 兔 Polyclonal unconjugated
anti-Mismatch Repair Protein 2 (MSH2) (AA 442-586) antibodyMSH2 适用: 人, 小鼠 WB, IHC, ELISA, FACS, ICC 宿主: 小鼠 Monoclonal 2E2C7 unconjugated
anti-Mismatch Repair Protein 2 (MSH2) (AA 337-583) antibodyMSH2 适用: 人, 小鼠, 大鼠 WB, IHC, IF, FACS, ICC 宿主: 兔 Polyclonal unconjugated
anti-Mismatch Repair Protein 2 (MSH2) (AA 1-934) antibodyMSH2 适用: 人 WB, IF, PLA 宿主: 兔 Polyclonal unconjugated
anti-Mismatch Repair Protein 2 (MSH2) (AA 337-583) antibodyMSH2 适用: 人 WB, IHC, IF, ICC 宿主: 小鼠 Monoclonal 6B4F7 unconjugated
anti-Mismatch Repair Protein 2 (MSH2) (AA 835-934) antibodyMSH2 适用: 人 WB, ELISA, PLA 宿主: 小鼠 Monoclonal 4B2 unconjugated
anti-Mismatch Repair Protein 2 (MSH2) (AA 442-586) antibodyMSH2 适用: 人 ELISA, FACS 宿主: 小鼠 Monoclonal 4F10D6 unconjugated
anti-Mismatch Repair Protein 2 (MSH2) (AA 224-313) antibodyMSH2 适用: 人, 犬 IHC 宿主: 小鼠 Monoclonal SYP-3551 unconjugated
anti-Mismatch Repair Protein 2 (MSH2) (C-Term) antibodyMSH2 适用: 人, 小鼠 IHC 宿主: 兔 Polyclonal unconjugated
anti-Mismatch Repair Protein 2 (MSH2) (AA 637-665) antibodyMSH2 适用: 人 WB, ELISA, IF, FACS 宿主: 兔 Polyclonal unconjugated
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应用备注
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Positive Control: A549 or HepG2 cells. Colon, Thyroid, Testis or Lymph Node.
Known Application: Flow Cytometry (1-2 μg/million cells), Western Blot (1-2 μg/mL),Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 min at RT),(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.
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限制
- 仅限研究用
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浓度
- 200 μg/mL
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缓冲液
- Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
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有效期
- 24 months
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- MSH2 (Mismatch Repair Protein 2 (MSH2))
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别名
- MSH2
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背景
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BAT26, COCA1, DNA mismatch repair protein Msh2, FCC1, hMSH2, HNPCC1, LCFS2, MSH2, MutS homolog 2, MutS homolog 2 colon cancer nonpolyposis type 1, MutS protein homolog 2
A549 or HepG2 cells. Colon, Testis or Lymph Node., Thyroid, Human Testis, Mouse Testis, Rat Testis, Hamster Testis, Guinea pig Testis, K-562 or HeLa
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分子量
- 100kDa
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基因ID
- 4436, 597656
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途径
- DNA Damage Repair, Production of Molecular Mediator of Immune Response
抗原
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