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- 抗原 See all Patched 1 (PTCH1) 抗体
- Patched 1 (PTCH1)
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适用
- 人, 小鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This Patched 1 antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 产品特性
- Patched1 and 2 (PTCH1 and PTCH2) are twelve-pass transmembrane proteins that function as the receiving receptors for members of the Hedgehog family of proteins (1-4). In the absence of Hedgehog proteins, PTCH suppresses the otherwise constitutively active signaling receptor Smoothened (Smo) so that the Hedgehog signaling pathway is in the off state (5,6). Deactivating mutations that impair the ability of PTCH1 to suppress Smo are frequently found in patients with nevoid basal cell carcinoma syndrome (7,8). PTCH proteins have a sterol-sensing domain (SSD) also found in several proteins that function in cholesterol homeostasis, such as HMGCR (3-hydroxy-3-methylglutaryl coenzyme A-reductase) and SCAP (sterol regulatory element-binding protein-cleavage activating protein). However, the role of the SSD in Patched proteins is not clear (9,10).PTCH1 itself is a target of Hedgehog signaling (11), with elevated PTCH1 expression as a surrogate marker for Hedgehog pathway activation (12-14).
- 纯化方法
- Affinity purification
- 免疫原
- Recombinant protein of human PTCH1.
- 亚型
- IgG
- Top Product
- Discover our top product PTCH1 Primary Antibody
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anti-Patched 1 (PTCH1) (C-Term) antibody
Verified PTCH1 适用: 人, 小鼠 ELISA, IHC, IF 宿主: 山羊 Polyclonal unconjugated
anti-Patched 1 (PTCH1) antibodyPTCH1 适用: 人, 小鼠, 大鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Patched 1 (PTCH1) (AA 1214-1312) antibodyPTCH1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Patched 1 (PTCH1) (AA 213-422) antibodyPTCH1 适用: 小鼠 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Patched 1 (PTCH1) antibodyPTCH1 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Patched 1 (PTCH1) antibodyPTCH1 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Patched 1 (PTCH1) (N-Term) antibodyPTCH1 适用: 人, 小鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Patched 1 (PTCH1) (Internal Region) antibodyVerified PTCH1 适用: 人, 小鼠 WB, ELISA, IF 宿主: 山羊 Polyclonal unconjugated
anti-Patched 1 (PTCH1) (AA 770-970) antibodyPTCH1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Patched 1 (PTCH1) (C-Term) antibodyPTCH1 适用: 人, 小鼠, 大鼠, 斑马鱼, 犬, Cow, 马, 豚鼠, 兔 WB, IHC 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB 1:500-1:1000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.4
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freeze/thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- Store at -20°C.
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- 抗原
- Patched 1 (PTCH1)
- 别名
- PTCH (PTCH1 产品)
- 别名
- BCNS antibody, HPE7 antibody, NBCCS antibody, PTC antibody, PTC1 antibody, PTCH antibody, PTCH11 antibody, lep antibody, ptc1 antibody, ptc2 antibody, Ptch antibody, Ptch2 antibody, Ptc-1 antibody, XPtc1 antibody, patched antibody, patched1 antibody, A230106A15Rik antibody, Ptc antibody, Ptc1 antibody, mes antibody, patched 1 antibody, patched 1 L homeolog antibody, Protein patched homolog 1 antibody, PTCH1 antibody, ptch1 antibody, Ptch1 antibody, ptch1.L antibody, ptc-1 antibody
- 基因ID
- 5727
- UniProt
- Q13635
- 途径
- Hedgehog Signaling, Carbohydrate Homeostasis, Tube Formation
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