CD44 抗体
(8 references)-
- 抗原 See all CD44 抗体
- CD44
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适用
- 人, 小鼠, 犬, 马, Cat
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宿主
- 大鼠
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克隆类型
- 单克隆
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标记
- This CD44 antibody is un-conjugated
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应用范围
- Flow Cytometry (FACS), Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC)
- 特异性
- The rat monoclonal antibody IM7 reacts with an extracellular epitope of CD44 antigen (Phagocyte glycoprotein 1), an 80-95 kDa transmembrane glycoprotein (hyaladherin family) present on the most of cells and tissues (leukocytes, endothelial cells, mesenchymal cells, etc.), it is negative on platelets and hepatocytes. The antibody reacts with all isoforms of mouse CD44.
- 交叉反应 （详细）
- Human, Mouse, Canine (Dog), Equine (Horse), Feline (Cat)
- 纯化方法
- Purified by protein-G affinity chromatography.
- 纯度
- > 95 % (by SDS-PAGE)
- 免疫原
- Dexamethasone-induced cells of the SJL mouse spontaneous myeloid leukemia M1
- 克隆位点
- IM7
- 亚型
- IgG2b kappa
- Top Product
- Discover our top product CD44 Primary Antibody
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anti-CD44 (CD44) antibody
CD44 适用: 人, 小鼠 FACS, WB, IHC, ELISA, ICC 宿主: 小鼠 Monoclonal 8E2F3 unconjugated
anti-CD44 (CD44) antibodyKO Validated CD44 适用: 人 WB, IHC (p), IF, IP, IHC (fro), ICC, LCI 宿主: 兔 Polyclonal unconjugated
anti-CD44 (CD44) (AA 21-220) antibodyCD44 适用: 人 FACS, WB, IHC, ELISA, IF 宿主: 小鼠 Monoclonal 6G2D2 unconjugated
anti-CD44 (CD44) antibodyCD44 适用: 人, 小鼠, 大鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-CD44 (CD44) antibodyCD44 适用: 人 FACS, WB, IHC, ELISA, IHC (p), IP, Inhibition 宿主: 小鼠 Monoclonal MEM-85 unconjugated
anti-CD44 (CD44) antibodyCD44 适用: 人, 犬, Pig FACS, WB, IHC (p), IP 宿主: 小鼠 Monoclonal MEM-263 unconjugated
anti-CD44 (CD44) (AA 346-385) antibodyCD44 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-CD44 (CD44) (AA 148-247) antibodyCD44 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-CD44 (CD44) antibodyCD44 适用: 人 WB, IHC 宿主: 兔 Monoclonal unconjugated
anti-CD44 (CD44) (AA 36-194) antibodyCD44 适用: 人 FACS, WB, IHC, ELISA, ICC, Neut 宿主: 小鼠 Monoclonal 7F4F12 unconjugated
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- 应用备注
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Flow cytometry: Recommended dilution: 1 μg/mL, positive control: murine peripheral blood.
Immunohistochemistry (paraffin sections): Positive tissue: murine spleen.
Western blotting: Non-reducing conditions. - 限制
- 仅限研究用
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- 浓度
- 1 mg/mL
- 缓冲液
- Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Do not freeze.
- 储存条件
- 4 °C
- 储存方法
- Store at 2-8°C. Do not freeze.
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: "CD44 mobilization in allogeneic dendritic cell-T cell immunological synapse plays a key role in T cell activation." in: Journal of leukocyte biology, Vol. 84, Issue 1, pp. 134-42, (2008) (PubMed).
: "CD44 differentially activates mouse NK T cells and conventional T cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 177, Issue 1, pp. 268-79, (2006) (PubMed).
: "CD44 regulates arteriogenesis in mice and is differentially expressed in patients with poor and good collateralization." in: Circulation, Vol. 109, Issue 13, pp. 1647-52, (2004) (PubMed).
: "A role for CD44 in an antigen-induced murine model of pulmonary eosinophilia." in: The Journal of clinical investigation, Vol. 111, Issue 10, pp. 1563-70, (2003) (PubMed).
: "A novel PKC-regulated mechanism controls CD44 ezrin association and directional cell motility." in: Nature cell biology, Vol. 4, Issue 6, pp. 399-407, (2002) (PubMed).
: "Role of CD44 in activation-induced cell death: CD44-deficient mice exhibit enhanced T cell response to conventional and superantigens." in: International immunology, Vol. 14, Issue 9, pp. 1015-26, (2002) (PubMed).
: "Involvement of CD44 in leukocyte trafficking at the blood-retinal barrier." in: Journal of leukocyte biology, Vol. 72, Issue 6, pp. 1133-41, (2002) (PubMed).
: "Negative regulation of epithelium-neutrophil interactions via activation of CD44." in: American journal of physiology. Cell physiology, Vol. 280, Issue 3, pp. C423-32, (2001) (PubMed).
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: "CD44 mobilization in allogeneic dendritic cell-T cell immunological synapse plays a key role in T cell activation." in: Journal of leukocyte biology, Vol. 84, Issue 1, pp. 134-42, (2008) (PubMed).
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- 抗原
- CD44
- 别名
- CD44 (CD44 产品)
- 别名
- CDW44 antibody, CSPG8 antibody, ECMR-III antibody, HCELL antibody, HUTCH-I antibody, IN antibody, LHR antibody, MC56 antibody, MDU2 antibody, MDU3 antibody, MIC4 antibody, Pgp1 antibody, AU023126 antibody, AW121933 antibody, AW146109 antibody, HERMES antibody, Ly-24 antibody, Pgp-1 antibody, CD44A antibody, METAA antibody, RHAMM antibody, XCD44 antibody, cd44 antibody, cdw44 antibody, cspg8 antibody, ecmr-iii antibody, hcell antibody, lhr antibody, mc56 antibody, mdu2 antibody, mdu3 antibody, mic4 antibody, mutch-i antibody, pgp1 antibody, CD44 molecule (Indian blood group) antibody, syndecan 4 antibody, CD44 antigen antibody, CD44 molecule (Indian blood group) S homeolog antibody, CD44 antibody, SDC4 antibody, Cd44 antibody, cd44.S antibody
- 背景
- CD44 Molecule,CD44 is a transmembrane glycoprotein expressed on the surface of most cells, which serves as a receptor for hyaluronan. CD44 mediates angiogenesis, cell adhesion, proliferation and migration, it is thus important for lymphocyte activation, recirculation and homing, it can thus serve e.g. as a modulator of macrophage recruitment in response to pathogen. Although CD44 functions are essential for physiological activities of normal cells, elevated CD44 expression correlates with poor prognosis in many carcinomas, facilitating tumour growth and metastasis, antiapoptosis and directional motility of cancer cells.,PGP-I, HUTCH-I, ECMR-III, Hermes antigen, Hyaluronate receptor, Heparan sulfate proteoglycan, Epican, MC56, MIC4
- 基因ID
- 12505
- UniProt
- P15379
- 途径
- Glycosaminoglycan Metabolic Process, Autophagy, Negative Regulation of intrinsic apoptotic Signaling
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