(8 references)-
- 抗原 See all PPM1D 抗体
- PPM1D (Protein Phosphatase, Mg2+/Mn2+ Dependent, 1D (PPM1D))
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抗原表位
- AA 571-602, C-Term
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This PPM1D antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 纯化方法
- This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
- 免疫原
- This PPM1D antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 571-602 amino acids from the C-terminal region of human PPM1D.
- 克隆位点
- RB6018
- 亚型
- Ig Fraction
- Top Product
- Discover our top product PPM1D Primary Antibody
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anti-Protein Phosphatase, Mg2+/Mn2+ Dependent, 1D (PPM1D) (AA 201-300) antibody
PPM1D 适用: 人 WB, ELISA, IF (cc), IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Protein Phosphatase, Mg2+/Mn2+ Dependent, 1D (PPM1D) (AA 1-250) antibodyPPM1D 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Protein Phosphatase, Mg2+/Mn2+ Dependent, 1D (PPM1D) (AA 496-605) antibodyPPM1D 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 4D1 unconjugated
anti-Protein Phosphatase, Mg2+/Mn2+ Dependent, 1D (PPM1D) (C-Term) antibodyPPM1D 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Protein Phosphatase, Mg2+/Mn2+ Dependent, 1D (PPM1D) antibodyPPM1D 适用: 人, 小鼠 WB, ELISA, IHC (p), ICC 宿主: 小鼠 Monoclonal 7E11-C5 unconjugated
anti-Protein Phosphatase, Mg2+/Mn2+ Dependent, 1D (PPM1D) (AA 571-602), (C-Term) antibodyPPM1D 适用: 人 WB 宿主: 兔 Polyclonal RB6018 unconjugated
anti-Protein Phosphatase, Mg2+/Mn2+ Dependent, 1D (PPM1D) (AA 183-212) antibodyPPM1D 适用: 人 WB 宿主: 兔 Polyclonal RB33957 unconjugated
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- 应用备注
- WB: 1:1000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C.
- 有效期
- 6 months
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: "p53-Independent expression of wild-type p53-induced phosphatase 1 (Wip1) in methylmethane sulfonate-treated cancer cell lines and human tumors." in: The international journal of biochemistry & cell biology, Vol. 44, Issue 6, pp. 896-904, (2012) (PubMed).
: "Expression of a homeostatic regulator, Wip1 (wild-type p53-induced phosphatase), is temporally induced by c-Jun and p53 in response to UV irradiation." in: The Journal of biological chemistry, Vol. 285, Issue 12, pp. 9067-76, (2010) (PubMed).
: "Wild-type p53-induced phosphatase 1 dephosphorylates histone variant gamma-H2AX and suppresses DNA double strand break repair." in: The Journal of biological chemistry, Vol. 285, Issue 17, pp. 12935-47, (2010) (PubMed).
: "Oncogenic Wip1 phosphatase is inhibited by miR-16 in the DNA damage signaling pathway." in: Cancer research, Vol. 70, Issue 18, pp. 7176-86, (2010) (PubMed).
: "The oncogenic phosphatase WIP1 negatively regulates nucleotide excision repair." in: DNA repair, Vol. 9, Issue 7, pp. 813-23, (2010) (PubMed).
: "BRCA1-IRIS overexpression abrogates UV-induced p38MAPK/p53 and promotes proliferation of damaged cells." in: Oncogene, Vol. 29, Issue 38, pp. 5274-85, (2010) (PubMed).
: "Phosphorylation and degradation of MdmX is inhibited by Wip1 phosphatase in the DNA damage response." in: Cancer research, Vol. 69, Issue 20, pp. 7960-8, (2009) (PubMed).
: "The estrogen receptor alpha pathway induces oncogenic Wip1 phosphatase gene expression." in: Molecular cancer research : MCR, Vol. 7, Issue 5, pp. 713-23, (2009) (PubMed).
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: "p53-Independent expression of wild-type p53-induced phosphatase 1 (Wip1) in methylmethane sulfonate-treated cancer cell lines and human tumors." in: The international journal of biochemistry & cell biology, Vol. 44, Issue 6, pp. 896-904, (2012) (PubMed).
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- 抗原
- PPM1D (Protein Phosphatase, Mg2+/Mn2+ Dependent, 1D (PPM1D))
- 别名
- PPM1D (PPM1D 产品)
- 别名
- PP2C-DELTA antibody, WIP1 antibody, AV338790 antibody, Wip1 antibody, zgc:103518 antibody, ppm1d antibody, wu:fj44c08 antibody, zgc:55836 antibody, zgc:77316 antibody, protein phosphatase, Mg2+/Mn2+ dependent 1D antibody, protein phosphatase 1D magnesium-dependent, delta isoform antibody, protein phosphatase, Mg2+/Mn2+ dependent, 1D antibody, protein phosphatase, Mg2+/Mn2+ dependent, 1Db antibody, protein phosphatase, Mg2+/Mn2+ dependent 1D L homeolog antibody, protein phosphatase, Mg2+/Mn2+ dependent, 1Da antibody, PPM1D antibody, Ppm1d antibody, ppm1db antibody, ppm1d.L antibody, ppm1da antibody
- 背景
- PPM1D is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. Expression of this PPM1D gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. The PPM1D gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development.
- 分子量
- 66675
- NCBI登录号
- NP_003611
- UniProt
- O15297
- 途径
- p53 Pathway, Cell Division Cycle
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