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- 抗原 See all MKNK2 抗体
- MKNK2 (MAP Kinase Interacting serine/threonine Kinase 2 (MKNK2))
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抗原表位
- AA 70-100, N-Term
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This MKNK2 antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 预测反应
- M, Rat
- 纯化方法
- This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
- 免疫原
- This MNK2 (MKNK2) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 70-100 amino acids from the N-terminal region of human MNK2 (MKNK2).
- 克隆位点
- RB5445
- 亚型
- Ig Fraction
- Top Product
- Discover our top product MKNK2 Primary Antibody
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anti-MAP Kinase Interacting serine/threonine Kinase 2 (MKNK2) (AA 1-158) antibody
MKNK2 适用: 人 WB, ELISA, PLA 宿主: 小鼠 Monoclonal 2A10 unconjugated
anti-MAP Kinase Interacting serine/threonine Kinase 2 (MKNK2) (AA 1-158) antibodyMKNK2 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 4F11 unconjugated
anti-MAP Kinase Interacting serine/threonine Kinase 2 (MKNK2) (AA 36-85) antibodyMKNK2 适用: 人, 小鼠, 大鼠, 犬, 豚鼠, 马, 斑马鱼, Bat, 猴, Pig WB, IHC (p), IHC 宿主: 兔 Polyclonal unconjugated
anti-MAP Kinase Interacting serine/threonine Kinase 2 (MKNK2) (AA 41-158) antibodyMKNK2 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-MAP Kinase Interacting serine/threonine Kinase 2 (MKNK2) (AA 1-100) antibodyMKNK2 适用: 小鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro), ICC 宿主: 兔 Polyclonal unconjugated
anti-MAP Kinase Interacting serine/threonine Kinase 2 (MKNK2) (Internal Region) antibodyMKNK2 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-MAP Kinase Interacting serine/threonine Kinase 2 (MKNK2) (AA 1-158) antibodyMKNK2 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-MAP Kinase Interacting serine/threonine Kinase 2 (MKNK2) (Internal Region) antibodyMKNK2 适用: 人, 小鼠, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-MAP Kinase Interacting serine/threonine Kinase 2 (MKNK2) (AA 1-414) antibodyMKNK2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-MAP Kinase Interacting serine/threonine Kinase 2 (MKNK2) (N-Term) antibodyMKNK2 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB: 1:1000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
- 有效期
- 6 months
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- 抗原
- MKNK2 (MAP Kinase Interacting serine/threonine Kinase 2 (MKNK2))
- 别名
- MNK2 (MKNK2) (MKNK2 产品)
- 别名
- GPRK7 antibody, MNK2 antibody, gprk7 antibody, mnk2 antibody, 2010016G11Rik antibody, Gprk7 antibody, Mnk2 antibody, mknk2 antibody, wu:fb37e05 antibody, wz5090 antibody, fi34c11 antibody, wu:fi34c11 antibody, wu:fi41e12 antibody, zgc:55587 antibody, MAP kinase interacting serine/threonine kinase 2 antibody, MAP kinase-interacting serine/threonine kinase 2 antibody, MAP kinase interacting serine/threonine kinase 2b antibody, MAP kinase interacting serine/threonine kinase 2 L homeolog antibody, MAP kinase interacting serine/threonine kinase 2a antibody, MKNK2 antibody, mknk2 antibody, Mknk2 antibody, mknk2b antibody, mknk2.L antibody, mknk2a antibody
- 背景
- MAP kinase-interacting kinase 1 (Mnk1) and Mnk2, members of the Ser/Thr protein kinase family, bind tightly to the growth factor-regulated MAP kinases, Erk1 and Erk2. Erk and p38 phosphorylate MNK1 and Mnk2, which stimulates their in vitro kinase activity toward a substrate, eukaryotic initiation factor-4E (eIF-4E). Overexpression of Mnk2 results in increased phosphorylation of endogenous eIF-4E, showing that it can act as an eIF-4E kinase in vivo. Mnk2 may play a role in the response to environmental stress and cytokines. This ubiquitiously expressed protein appears to regulate transcription by phosphorylating eIF-4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. Expression of active mutants of MNK1 and MNK2 in 293 cells diminishes cap-dependent translation relative to cap-independent translation in a transient reporter assay. Human Mnk2 is homologous to murine Mnk2 (approximately 94 % identical) and human Mnk1 (71 % identical). In vitro phosphorylation studies show that Mnk2 is a significantly better substrate than Mnk1 for extracellular signal-regulated kinase 2 (Erk2), p38MAPKalpha, and p38MAPKbeta. Mnk2 has also been shown to interact with the C-terminal regions of eIF-4G1 and eIF-4G2.
- 分子量
- 51875
- 基因ID
- 2872
- NCBI登录号
- NP_060042, NP_951009
- UniProt
- Q9HBH9
- 途径
- MAPK Pathway
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