FADD 抗体 (Sepharose)
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- 抗原 See all FADD 抗体
- FADD (Fas (TNFRSF6)-Associated Via Death Domain (FADD))
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This FADD antibody is conjugated to Sepharose
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应用范围
- Western Blotting (WB), ELISA, Immunoprecipitation (IP)
- 特异性
- Human FADD
- 产品特性
- Mouse Anti-Human FADD-SEPH
- 纯化方法
- Purified
- 免疫原
- Recombinant FADD
- 克隆位点
- 1A11
- 亚型
- IgG1
- Top Product
- Discover our top product FADD Primary Antibody
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- 应用备注
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- Applications: ELISA - Quality tested WB - Quality tested IP - Quality tested
- Working Dilutions: ELISA Purified (UNLB) antibody 0.5 g/mL Immunoblotting HRP conjugate 1:4,000 - 1:8,000 Immunoprecipitation SEPH conjugate 40 L
- 限制
- 仅限研究用
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- 缓冲液
- 50 tests in 2.0 mL of borate buffered saline, pH 8.2. No preservatives or amine-containing buffer salts added
- 储存液
- Without preservative
- 注意事项
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Protect conjugated products from light.
Each reagent is stable for the period shown on the bottle label if stored as directed. - 储存条件
- 4 °C
- 储存方法
- Store at 2-8°C
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- 抗原
- FADD (Fas (TNFRSF6)-Associated Via Death Domain (FADD))
- 别名
- FADD (FADD 产品)
- 别名
- MORT1 antibody, Mort1/FADD antibody, Mort1 antibody, TNFRSF6 antibody, adaptor antibody, fadd antibody, mort1 antibody, xfadd antibody, Fas associated via death domain antibody, Fas (TNFRSF6)-associated via death domain antibody, Fas associated via death domain S homeolog antibody, Fas (tnfrsf6)-associated via death domain antibody, FADD antibody, Fadd antibody, fadd.S antibody, fadd antibody
- 背景
- Fas-associated death domain (FADD, also known as MORT1) is an important apoptosis adapter molecule involved in the Fas-mediated cell death pathway. FADD associates with the intracellular domain of FAS (CD95/APO-1) through their respective C-terminal death domains (DD). The N-terminal region of FADD contains a death effectors domain (DED) which recruits and binds cytosolic proteins such as FLICE/caspase-8. The subsequent activation of FLICE by proteolytic cleavage leads to the activation of the caspase-mediated (ICE-related proteases) apoptotic cascade. Overexpression of FADD induces apoptosis which is inhibited by CrmA, a specific inhibitor of the interleukin-1 β -converting enzyme. FADD has also been shown under certain circumstances to promote cell survival and proliferation.
- 途径
- Apoptosis, TLR signaling, Activation of Innate immune Response, Positive Regulation of Endopeptidase Activity, Toll-Like Receptors Cascades
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