IFT57 抗体 (Internal Region)
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- 抗原 See all IFT57 抗体
- IFT57 (Intraflagellar Transport 57 Homolog (IFT57))
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抗原表位
- Internal Region
- 适用
- 人, 小鼠, 大鼠, Cow
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宿主
- 山羊
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克隆类型
- 多克隆
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标记
- This IFT57 antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 特异性
- This antibody reacts to HIPPI.
- 交叉反应 （详细）
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Species reactivity (expected):Rat, Bovine.
Species reactivity (tested):Human, Mouse. - 纯化方法
- Affinity chromatography
- 免疫原
- Peptide with sequence C-EQPQEYDDPNATISN, from the internal region of the protein sequence
- Top Product
- Discover our top product IFT57 Primary Antibody
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anti-Intraflagellar Transport 57 Homolog (IFT57) (AA 170-429) antibody
IFT57 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Intraflagellar Transport 57 Homolog (IFT57) (AA 1-429) antibodyIFT57 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Intraflagellar Transport 57 Homolog (IFT57) (AA 214-312) antibodyIFT57 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1G8 unconjugated
anti-Intraflagellar Transport 57 Homolog (IFT57) (Internal Region) antibodyIFT57 适用: 人, 小鼠, 大鼠, 犬 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Intraflagellar Transport 57 Homolog (IFT57) (AA 159-193) antibodyIFT57 适用: 人 WB 宿主: 兔 Polyclonal RB57869 unconjugated
anti-Intraflagellar Transport 57 Homolog (IFT57) antibodyIFT57 适用: 人, 小鼠 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Intraflagellar Transport 57 Homolog (IFT57) (AA 214-312) antibodyIFT57 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Intraflagellar Transport 57 Homolog (IFT57) (Internal Region) antibodyVerified IFT57 适用: 人, 小鼠 WB, IHC, ELISA 宿主: 山羊 Polyclonal unconjugated
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- 应用备注
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Peptide ELISA: 1/8000. Western Blot: 1 - 3 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - 限制
- 仅限研究用
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- 浓度
- 0,5 mg/mL
- 缓冲液
- Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin
- 储存液
- Sodium azide
- 注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freezing and thawing.
- 储存条件
- 4 °C/-20 °C
- 储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- 抗原
- IFT57 (Intraflagellar Transport 57 Homolog (IFT57))
- 别名
- HIP1-Interacting Protein (IFT57 产品)
- 别名
- Esrrbl1 antibody, 4833420A15Rik antibody, Hippi antibody, MHS4R2 antibody, ESRRBL1 antibody, HIPPI antibody, intraflagellar transport 57 antibody, intraflagellar transport 57 S homeolog antibody, Ift57 antibody, IFT57 antibody, ift57.S antibody
- 背景
- HIPPI was identified as a protein that interacts with HIP1 (Huntingtin-interacting protein 1). HIPPI mRNA is expressed in the brain. It is present in all regions of the brain, and to a lesser extent in spinal cord. It is also expressed abundantly in heart, kidney, and lung, with weaker expression in all other tissues tested. HIPPI is expressed in the Golgi apparatus of neurons where it partly colocalizes with HIP1. HIPPI forms a heterodimer with HIP1. The availability of free HIP1 is modulated by polyglutamine length within huntingtin, with disease-associated polyglutamine expansion favoring the formation of proapoptotic HIPPI-HIP1 heterodimers. These heterodimers can recruit procaspase-8 into a complex of HIPPI, HIP1, and procaspase-8 and launch apoptosis through components of the extrinsic cell death pathway. This novel non-receptor-mediated pathway for activating caspase-8 might contribute to neuronal death in Huntington disease.Synonyms: DERP8, Dermal papilla-derived protein 8, ESRRBL1, Estrogen-related receptor beta-like protein 1, HIPPI, IFT57, Intraflagellar transport protein 57 homolog, MHS4R2
- 基因ID
- 55081, 9606
- UniProt
- Q9NWB7
- 途径
- Hedgehog Signaling, Positive Regulation of Endopeptidase Activity
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