Patched 1 抗体 (Internal Region)
-
- 抗原 See all Patched 1 (PTCH1) 抗体
- Patched 1 (PTCH1)
-
抗原表位
- Internal Region
-
适用
- 斑马鱼
-
宿主
- 山羊
-
克隆类型
- 多克隆
-
标记
- This Patched 1 antibody is un-conjugated
-
应用范围
- Immunofluorescence (IF), Enzyme Immunoassay (EIA)
- 序列
- C-QTGSKKEPFN YSQ
- 特异性
- This antibody recognizes internal PTCH1.
- 交叉反应 （详细）
- Species reactivity (tested):Zebrafish.
- 纯化方法
- Ammonium Sulphate Precipitation followed by antigen Affinity Chromatography using the immunizing peptide.
- 免疫原
- Peptide with sequence from the internal region of the protein sequence according to NP_571063.1
- Top Product
- Discover our top product PTCH1 Primary Antibody
-
anti-Patched 1 (PTCH1) (C-Term) antibody
Verified PTCH1 适用: 人, 小鼠 ELISA, IHC, IF 宿主: 山羊 Polyclonal unconjugated
anti-Patched 1 (PTCH1) antibodyPTCH1 适用: 人, 小鼠, 大鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Patched 1 (PTCH1) (AA 1214-1312) antibodyPTCH1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Patched 1 (PTCH1) (AA 213-422) antibodyPTCH1 适用: 小鼠 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Patched 1 (PTCH1) antibodyPTCH1 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Patched 1 (PTCH1) antibodyPTCH1 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Patched 1 (PTCH1) (N-Term) antibodyPTCH1 适用: 人, 小鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Patched 1 (PTCH1) (Internal Region) antibodyVerified PTCH1 适用: 人, 小鼠 WB, ELISA, IF 宿主: 山羊 Polyclonal unconjugated
anti-Patched 1 (PTCH1) (AA 770-970) antibodyPTCH1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Patched 1 (PTCH1) (C-Term) antibodyPTCH1 适用: 人, 小鼠, 大鼠, 斑马鱼, 犬, Cow, 马, 豚鼠, 兔 WB, IHC 宿主: 兔 Polyclonal unconjugated
-
- 应用备注
-
Peptide ELISA: Antibody Detection Limit Dilution: 1/32000. Immunofluorescence studies of Zebrafish tumors: 1-3 μg/mL (Ju et al, Mol Cancer.2009 Jun25,8: 40. PMID: 19555497).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - 限制
- 仅限研究用
-
- 浓度
- 0.5 mg/mL
- 缓冲液
- Tris saline, pH 7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer.
- 储存液
- Sodium azide
- 注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freezing and thawing.
- 储存条件
- 4 °C/-20 °C
- 储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
-
- 抗原
- Patched 1 (PTCH1)
- 别名
- PTCH1 (PTCH1 产品)
- 别名
- BCNS antibody, HPE7 antibody, NBCCS antibody, PTC antibody, PTC1 antibody, PTCH antibody, PTCH11 antibody, lep antibody, ptc1 antibody, ptc2 antibody, Ptch antibody, Ptch2 antibody, Ptc-1 antibody, XPtc1 antibody, patched antibody, patched1 antibody, A230106A15Rik antibody, Ptc antibody, Ptc1 antibody, mes antibody, patched 1 antibody, patched 1 L homeolog antibody, Protein patched homolog 1 antibody, PTCH1 antibody, ptch1 antibody, Ptch1 antibody, ptch1.L antibody, ptc-1 antibody
- 背景
- PTCH (Patched protein homolog 1) is a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). PTCH associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal.PTCH has a tumor suppressor function, as inactivation of this protein is probably a necessary, if not sufficient step for tumorigenesis. PTCH is expressed in the adult brain, lung, liver, heart, placenta, skeletal muscle, pancreas and kidney. It is also expressed in tumor cells but not in normal skin. During development PTCH is found in all major target tissues of sonic hedgehog, such as the ventral neural tube, somites, and tissues surrounding the zone of polarizing activity of the limb bud. Defects in PTCH are probably the cause of basal cell nevus syndrome also known as Gorlin syndrome or Gorlin-Goltz syndrome.Synonyms: PTC, PTC1, PTCH, Patched 1, Protein patched homolog 1
- 基因ID
- 30181, 7955
- UniProt
- Q98864
- 途径
- Hedgehog Signaling, Carbohydrate Homeostasis, Tube Formation
-
