MARK1 抗体 (N-Term)
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- 抗原 See all MARK1 抗体
- MARK1 (MAP/microtubule Affinity-Regulating Kinase 1 (MARK1))
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抗原表位
- N-Term
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适用
- 人, 小鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This MARK1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
- 特异性
- This antibody reacts to MARK1.
- 纯化方法
- Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS
- 免疫原
- This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human MARK1.
- 亚型
- Ig Fraction
- Top Product
- Discover our top product MARK1 Primary Antibody
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anti-MAP/microtubule Affinity-Regulating Kinase 1 (MARK1) (AA 560-700) antibody
MARK1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-MAP/microtubule Affinity-Regulating Kinase 1 (MARK1) (N-Term) antibodyMARK1 适用: 人, 猴, 兔, Bat, Cow, 犬 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-MAP/microtubule Affinity-Regulating Kinase 1 (MARK1) (N-Term) antibodyMARK1 适用: 人, 猴, 兔, 马 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-MAP/microtubule Affinity-Regulating Kinase 1 (MARK1) (Internal Region) antibodyMARK1 适用: 人, 猴, 兔, Bat IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-MAP/microtubule Affinity-Regulating Kinase 1 (MARK1) (AA 6-40), (N-Term) antibodyMARK1 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB8545 unconjugated
anti-MAP/microtubule Affinity-Regulating Kinase 1 (MARK1) (Center) antibodyMARK1 适用: 人, 小鼠, 大鼠, 斑马鱼 WB, IHC, IF, IC 宿主: 兔 Polyclonal unconjugated
anti-MAP/microtubule Affinity-Regulating Kinase 1 (MARK1) (AA 6-40) antibodyMARK1 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-MAP/microtubule Affinity-Regulating Kinase 1 (MARK1) antibodyMARK1 适用: 人, 小鼠, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-MAP/microtubule Affinity-Regulating Kinase 1 (MARK1) antibodyMARK1 适用: 人, 小鼠 IHC 宿主: 兔 Polyclonal unconjugated
anti-MAP/microtubule Affinity-Regulating Kinase 1 (MARK1) antibodyMARK1 适用: 人, 猴, 兔, Cow, 犬 IHC (p) 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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ELISA: 1/1,000. Western blotting: 1/200 - 1/500. Immunohistochemistry: 1/10 - 1/50.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 0.25 mg/mL
- 缓冲液
- PBS with 0.09 % (W/V) sodium azide
- 储存液
- Sodium azide
- 注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freezing and thawing.
- 储存条件
- 4 °C/-20 °C
- 储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
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- 抗原
- MARK1 (MAP/microtubule Affinity-Regulating Kinase 1 (MARK1))
- 别名
- MARK1 (MARK1 产品)
- 别名
- MGC80341 antibody, MARK1 antibody, AW491150 antibody, B930025N23Rik antibody, Emk3 antibody, Par-1c antibody, mKIAA1477 antibody, mPar-1c antibody, MARK antibody, Par1c antibody, MAP/microtubule affinity-regulating kinase 1 S homeolog antibody, microtubule affinity regulating kinase 1 antibody, MAP/microtubule affinity-regulating kinase 1 antibody, MAP/microtubule affinity regulating kinase 1 antibody, mark1.S antibody, MARK1 antibody, mark1 antibody, Mark1 antibody
- 背景
- MARK is a family of kinases that is known for its involvement in establishing cell polarity and in phosphorylating tau protein during Alzheimer neurodegeneration. Expression of MARK causes the phosphorylation of MAPs at their KXGS motifs, thereby detaching MAPs from the microtubules and thus facilitating the transport of particles. This occurs without impairing the intrinsic activity of motors because the velocity during active movement remains unchanged. In primary retinal ganglion cells, transfection with tau leads to the inhibition of axonal transport of mitochondria, APP vesicles, and other cell components which leads to starvation of axons and vulnerability against stress. This transport inhibition can be rescued by phosphorylating tau with MARKSynonyms: MAP/Microtubule Affinity-Regulating Kinase 1, MARK, Serine/threonine-protein kinase MARK1
- 基因ID
- 4139
- NCBI登录号
- NP_061120
- UniProt
- Q9P0L2
- 途径
- SARS-CoV-2 Protein Interactome, The Global Phosphorylation Landscape of SARS-CoV-2 Infection
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