IFNB1 抗体 (Middle Region)
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- 抗原 See all IFNB1 抗体
- IFNB1 (Interferon, beta 1, Fibroblast (IFNB1))
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抗原表位
- Middle Region
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适用
- 人, 小鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This IFNB1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- 特异性
- This antibody recognises interferon beta (IFN-beta), a 22 kDa member of the type I alpha/beta interferon family.
- 交叉反应 （详细）
- Species reactivity (tested):Human and Mouse.
- 纯化方法
- Purified
- 免疫原
- A 17 amino acid peptide located near the centre of human Interferon beta.
- 亚型
- IgG
- Top Product
- Discover our top product IFNB1 Primary Antibody
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anti-Interferon, beta 1, Fibroblast (IFNB1) (AA 22-187) antibody
IFNB1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Interferon, beta 1, Fibroblast (IFNB1) (AA 101-187) antibodyIFNB1 适用: 人, 大鼠 ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Interferon, beta 1, Fibroblast (IFNB1) antibodyIFNB1 适用: 人 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal C5 unconjugated
anti-Interferon, beta 1, Fibroblast (IFNB1) (AA 39-66) antibodyIFNB1 适用: 人 WB, IHC, ELISA, FACS 宿主: 兔 Polyclonal unconjugated
anti-Interferon, beta 1, Fibroblast (IFNB1) (AA 39-66), (N-Term) antibodyIFNB1 适用: 人 WB, IHC (p), FACS 宿主: 兔 Polyclonal RB22040 unconjugated
anti-Interferon, beta 1, Fibroblast (IFNB1) (AA 23-169) antibodyIFNB1 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Interferon, beta 1, Fibroblast (IFNB1) (AA 23-169) antibodyIFNB1 适用: 大鼠 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal C2 unconjugated
anti-Interferon, beta 1, Fibroblast (IFNB1) (AA 22-187) antibodyIFNB1 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Interferon, beta 1, Fibroblast (IFNB1) (AA 1-187) antibodyIFNB1 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Interferon, beta 1, Fibroblast (IFNB1) (Center) antibodyIFNB1 适用: 人, 小鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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Western Blot: 5 μg/mL. This Interferon beta antibody detects a band of approximately 15 kDa in A20 cell lysates.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - 限制
- 仅限研究用
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- 浓度
- 1.0 mg/mL
- 缓冲液
- PBS, 0.02 % Sodium Azide
- 储存液
- Sodium azide
- 注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freezing and thawing.
- 储存条件
- 4 °C/-20 °C
- 储存方法
- Store the antibody undiluted at 2-8 °C for up to one month or (in aliquots) at -20 °C for longer.
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- 抗原
- IFNB1 (Interferon, beta 1, Fibroblast (IFNB1))
- 别名
- IFNB / Interferon beta (IFNB1 产品)
- 别名
- IFB antibody, IFF antibody, IFNB antibody, IFN-beta antibody, Ifb antibody, Ifnb antibody, IFNb antibody, interferon beta 1 antibody, interferon beta 1, fibroblast antibody, interferon, beta 1, fibroblast antibody, IFNB1 antibody, Ifnb1 antibody
- 背景
- The mammalian type I Inteferons (IFN1) are produced in response to viral infection and other inducers. They are divided into alpha and beta subtypes leukocytes and fibroblasts reactivity. The human IFN alphas are encoded by a family of at least 15 different genes, while IFN beta is the unique member of its subtype. There is approximately 50 % amino acid homology between the alpha and beta subtypes. Both IFN subtypes are pleiotropic cytokines and have a similar range of biological activities. Differences between alpha subtypes, and between IFN alpha and betas, are in potency and cell type specific activities. In particular, IFN beta elicits a markedly higher antiproliferation response in some cell types such as, embryonal carcinoma, melanoma and melanocytes than do IFN alphas. Higher potency of IFN beta in treatment of multiple sclerosis and certain cancers has been observed. Type I IFNs signal through binding to a common cell surface receptor. Two chains of the receptor, IFNAR1 and IFNAR2, have been identified. Both chains are necessary for function and in the absence of either there is neither high affinity binding nor biological activity. The intracellular portions of the receptor subunits are bound by tyrosine kinases, Jak1 and Tyk2, members of the Janus kinase family. Upon ligand binding these kinases are activated and phosphorylate members of the STAT family of transcription factors, as well as IFNAR1 and 2.Synonyms: Fibroblast interferon, IFB, IFN-beta, IFNB1
- 基因ID
- 3456
- NCBI登录号
- NP_002167
- UniProt
- P01574
- 途径
- JAK/STAT Signaling, TCR Signaling, TLR signaling, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity, Hepatitis C, Autophagy, Inflammasome
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