CYP11A1 抗体 (C-Term)
(1 reference)-
- 抗原 See all CYP11A1 抗体
- CYP11A1 (Cytochrome P450, Family 11, Subfamily A, Polypeptide 1 (CYP11A1))
-
抗原表位
- AA 507-521, C-Term
-
适用
- 人
-
宿主
- 兔
-
克隆类型
- 多克隆
-
标记
- This CYP11A1 antibody is un-conjugated
-
应用范围
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
- 原理
- Rabbit IgG polyclonal antibody for Cholesterol side-chain cleavage enzyme, mitochondrial(CYP11A1) detection. Tested with WB, IHC-P, IHC-F in Human.
- 序列
- ISFTFWPFNQ EATQQ
- 交叉反应 （详细）
- No cross reactivity with other proteins.
- 产品特性
-
Rabbit IgG polyclonal antibody for Cholesterol side-chain cleavage enzyme, mitochondrial(CYP11A1) detection. Tested with WB, IHC-P, IHC-F in Human.
Gene Name: cytochrome P450, family 11, subfamily A, polypeptide 1
Protein Name: Cholesterol side-chain cleavage enzyme, mitochondrial - 纯化方法
- Immunogen affinity purified.
- 免疫原
- A synthetic peptide corresponding to a sequence at the C-terminus of human CYP11A1(507-521aa ISFTFWPFNQEATQQ).
- 亚型
- IgG
- Top Product
- Discover our top product CYP11A1 Primary Antibody
-
anti-Cytochrome P450, Family 11, Subfamily A, Polypeptide 1 (CYP11A1) (AA 321-420) antibody
CYP11A1 适用: 人, 大鼠, 小鼠, Cow WB, IF (p), IHC (p), FACS, IF (cc), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Cytochrome P450, Family 11, Subfamily A, Polypeptide 1 (CYP11A1) (AA 40-320) antibodyCYP11A1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Cytochrome P450, Family 11, Subfamily A, Polypeptide 1 (CYP11A1) (AA 288-337) antibodyCYP11A1 适用: 人 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Cytochrome P450, Family 11, Subfamily A, Polypeptide 1 (CYP11A1) (C-Term) antibodyCYP11A1 适用: 人 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Cytochrome P450, Family 11, Subfamily A, Polypeptide 1 (CYP11A1) antibodyCYP11A1 适用: 人, 大鼠, 小鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Cytochrome P450, Family 11, Subfamily A, Polypeptide 1 (CYP11A1) (AA 1-521) antibodyCYP11A1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Cytochrome P450, Family 11, Subfamily A, Polypeptide 1 (CYP11A1) (C-Term) antibodyCYP11A1 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Cytochrome P450, Family 11, Subfamily A, Polypeptide 1 (CYP11A1) (AA 392-521) antibodyCYP11A1 适用: 人 WB, ELISA, ICC, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Cytochrome P450, Family 11, Subfamily A, Polypeptide 1 (CYP11A1) (AA 40-521) antibodyCYP11A1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Cytochrome P450, Family 11, Subfamily A, Polypeptide 1 (CYP11A1) (AA 44-287) antibodyCYP11A1 适用: Pig WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
-
- 应用备注
-
WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
IHC-F: Concentration: 0.5-1 μg/mL, Tested Species: Human
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users. - 说明
-
Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P) and IHC(F).
- 限制
- 仅限研究用
-
- 状态
- Lyophilized
- 溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
- 浓度
- 500 μg/mL
- 缓冲液
- Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
- 储存液
- Thimerosal (Merthiolate), Sodium azide
- 注意事项
- This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.
- 注意事项
- Avoid repeated freezing and thawing.
- 储存条件
- 4 °C/-20 °C
- 储存方法
-
At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing. - 有效期
- 12 months
-
-
: "Abnormal apoptosis of trophoblastic cells is related to the up-regulation of CYP11A gene in placenta of preeclampsia patients." in: PLoS ONE, Vol. 8, Issue 3, pp. e59609, (2013) (PubMed).
-
: "Abnormal apoptosis of trophoblastic cells is related to the up-regulation of CYP11A gene in placenta of preeclampsia patients." in: PLoS ONE, Vol. 8, Issue 3, pp. e59609, (2013) (PubMed).
-
- 抗原
- CYP11A1 (Cytochrome P450, Family 11, Subfamily A, Polypeptide 1 (CYP11A1))
- 别名
- CYP11A1 (CYP11A1 产品)
- 别名
- CYP11A antibody, CYP11A1 antibody, CYPXIA1 antibody, P450SCC antibody, Cyp11a antibody, Cypxia1 antibody, D9Ertd411e antibody, P450scc antibody, Scc antibody, cscc antibody, P450(scc) antibody, SSC antibody, cytochrome P450 family 11 subfamily A member 1 antibody, cholesterol side-chain cleavage enzyme, mitochondrial-like antibody, cytochrome P450 cholesterol side-chain cleavage antibody, cytochrome P450, family 11, subfamily a, polypeptide 1 antibody, cytochrome P450, family 11, subfamily A, polypeptide 1 antibody, CYP11A1 antibody, LOC101827747 antibody, Cyp11a1 antibody
- 背景
-
CYP11A1(Cytochrome p450, family 11, subfamily A, polypeptide 1), also called CYTOCHROME P450SCC, CYTOCHROME P450C11A1 or CYP11A, is a mitochondrial enzyme associated with the conversion of cholesterol to pregnenolone. CYP11A1 is a member of the cytochrome P450 superfamily of enzymes. The CYP11A1 gene is mapped on 15q24.1. Expression of the CYP11A1 gene may play a role in skin physiology and pathology and that cutaneous proopiomelanocortin activity may be autoregulated by a feedback mechanism involving glucocorticoids synthesized locally by Slominski et al. Using in vitro studies, CYP11A1 catalyzed the side-chain cleavage of 7-dehydrocholesterol to form 7-dehydropregnenolone. In addition, CYP11A1 catalyzed the metabolism of biologically inert vitamin D3, which is formed from 7-dehydrocholesterol, to form 2 hydroxylated products, 20-hydroxyvitamin D3 and 20, 22-dihydroxyvitamin D3. Mutations in the CYP11A1 gene cause congenital adrenal insufficiency with partial or complete 46, XY sex reversal.
Synonyms: Cholesterol 20 22 desmolase antibody|Cholesterol desmolase antibody|Cholesterol monooxygenase(side chain cleaving) antibody|Cholesterol side chain cleavage enzyme antibody|Cholesterol side chain cleavage enzyme mitochondrial antibody|Cholesterol side-chain cleavage enzyme antibody|CP11A_HUMAN antibody|CYP 11A antibody|CYP11A antibody|CYP11A1 antibody|CYPXIA1 antibody|Cytochrome P450 11A1 antibody|Cytochrome P450 11A1 mitochondrial antibody|Cytochrome P450 family 11 subfamily A polypeptide 1 antibody|Cytochrome P450 subfamily XIA(cholesterol side chain cleavage) antibody|Cytochrome P450 subfamily XIA antibody|Cytochrome P450(scc) antibody|Cytochrome P450C11A1 antibody|mitochondrial antibody|P450(scc) antibody|P450SCC antibody|Steroid 20 22 lyase antibody - UniProt
- P05108
- 途径
- Metabolism of Steroid Hormones and Vitamin D, Steroid Hormone Biosynthesis, C21-Steroid Hormone Metabolic Process, Cellular Response to Molecule of Bacterial Origin
-
