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- 抗原 See all DCC 抗体
- DCC (Deleted in Colorectal Carcinoma (DCC))
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抗原表位
- AA 162-178, N-Term
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适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This DCC antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- 原理
- Rabbit IgG polyclonal antibody for Netrin receptor DCC(DCC) detection. Tested with WB, IHC-P in Human,Mouse,Rat.
- 序列
- EVIGEPMPTI HWQKNQQ
- 交叉反应 （详细）
- No cross reactivity with other proteins.
- 产品特性
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Rabbit IgG polyclonal antibody for Netrin receptor DCC(DCC) detection. Tested with WB, IHC-P in Human,Mouse,Rat.
Gene Name: deleted in colorectal carcinoma
Protein Name: Netrin receptor DCC - 纯化方法
- Immunogen affinity purified.
- 免疫原
- A synthetic peptide corresponding to a sequence at the N-terminus of human DCC(162-178aa EVIGEPMPTIHWQKNQQ), identical to the related mouse sequence, and different from the related rat sequence by one amino acid.
- 亚型
- IgG
- Top Product
- Discover our top product DCC Primary Antibody
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anti-Deleted in Colorectal Carcinoma (DCC) (Middle Region) antibody
DCC 适用: 人, 小鼠, 大鼠, 兔, 犬, 豚鼠, 马, 斑马鱼 WB 宿主: 兔 Polyclonal unconjugated
anti-Deleted in Colorectal Carcinoma (DCC) (C-Term) antibodyDCC 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Deleted in Colorectal Carcinoma (DCC) antibodyDCC 适用: 人, 小鼠, 大鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Deleted in Colorectal Carcinoma (DCC) (AA 162-178) antibodyDCC 适用: 人, 小鼠, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Deleted in Colorectal Carcinoma (DCC) (Internal Region) antibodyDCC 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Deleted in Colorectal Carcinoma (DCC) (AA 1048-1082), (C-Term) antibodyDCC 适用: 人 WB 宿主: 兔 Polyclonal RB51762 unconjugated
anti-Deleted in Colorectal Carcinoma (DCC) (AA 1079-1128) antibodyDCC 适用: 人, 小鼠, 大鼠, 兔, 犬, 豚鼠, 马, 斑马鱼, Pig, 非洲爪蟾 WB 宿主: 兔 Polyclonal unconjugated
anti-Deleted in Colorectal Carcinoma (DCC) (Internal Region) antibodyDCC 适用: 人, 小鼠, 大鼠 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Deleted in Colorectal Carcinoma (DCC) (AA 643-670) antibodyDCC 适用: 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB32203 unconjugated
anti-Deleted in Colorectal Carcinoma (DCC) (AA 642-670), (Middle Region) antibodyDCC 适用: 人, 小鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Mouse, Rat
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Predicted Species: Mouse, Rat, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users. - 说明
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Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
- 浓度
- 500 μg/mL
- 缓冲液
- Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
- 储存液
- Thimerosal (Merthiolate), Sodium azide
- 注意事项
- This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.
- 注意事项
- Avoid repeated freezing and thawing.
- 储存条件
- 4 °C/-20 °C
- 储存方法
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At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing. - 有效期
- 12 months
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- 抗原
- DCC (Deleted in Colorectal Carcinoma (DCC))
- 别名
- DCC (DCC 产品)
- 别名
- CRC18 antibody, CRCR1 antibody, IGDCC1 antibody, MRMV1 antibody, DCC antibody, zdcc antibody, C030036D22Rik antibody, Igdcc1 antibody, xdcc antibody, XDCCa antibody, dcca-A antibody, Dcc antibody, DCC netrin 1 receptor antibody, deleted in colorectal carcinoma antibody, netrin receptor DCC antibody, DCC antibody, dcc antibody, Dcc antibody, LOC100712666 antibody
- 背景
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DCC(Deleted IN Colorectal Carcinoma) also known as CRC18 or CRCR1. The DCC gene encodes a functional receptor for netrin and mediates axon outgrowth and the steering response. Heterozygous loss-of-function mutations in DCC can result in congenital mirror movements. Alterations in DCC occur frequently in colorectal cancer. Studying a YAC contig containing the entire DCC coding region, they showed that the DCC gene spans approximately 1.4 Mb. Vogelstein(1995) stated that the precise location of the DCC gene was though to be 18q21.3. DCC is a receptor or a component of a receptor that mediates the effects of netrin-1 on commissural axons, and they complement genetic evidence for interactions between DCC and netrin homologs in C. DCC protein could be detected in varying abundance in all specimens of normal colonic mucosa analyzed as well as in all specimens of adenomatous polyps, colorectal carcinoma and colorectal liver metastases. DCC may function as a tumor-suppressor protein by inducing apoptosis in settings in which ligand is unavailable(for example, during metastasis or tumor growth beyond local blood supply) through functional caspase cascades by a mechanism that requires cleavage of DCC at asp1290. Stein et al.(2001) concluded that DCC plays a central role in netrin signaling of axon growth and guidance independent of A2B receptor activation.
Synonyms: Colorectal cancer related chromosome sequence 18 antibody|Colorectal cancer suppressor antibody|CRC 18 antibody|CRC18 antibody|CRCR 1 antibody|CRCR1 antibody|DCC antibody|DCC_HUMAN antibody|Deleted in colorectal cancer protein antibody|Deleted in colorectal carcinoma antibody|Immunoglobulin superfamily DCC subclass member 1 antibody|Netrin receptor DCC antibody|Tumor suppressor protein DCC antibody - UniProt
- P43146
- 途径
- Regulation of Cell Size
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