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- 抗原 See all DCC 抗体
- DCC (Deleted in Colorectal Carcinoma (DCC))
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抗原表位
- AA 162-178
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适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This DCC antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- 纯化方法
- Antigen affinity
- 免疫原
- Amino acids 162-178 (EVIGEPMPTIHWQKNQQ-human) were used as the immunogen for this DCC antibody (100% mouse homology).
- 亚型
- IgG
- Top Product
- Discover our top product DCC Primary Antibody
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anti-Deleted in Colorectal Carcinoma (DCC) (Middle Region) antibody
DCC 适用: 人, 小鼠, 大鼠, 兔, 犬, 豚鼠, 马, 斑马鱼 WB 宿主: 兔 Polyclonal unconjugated
anti-Deleted in Colorectal Carcinoma (DCC) (C-Term) antibodyDCC 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Deleted in Colorectal Carcinoma (DCC) antibodyDCC 适用: 人, 小鼠, 大鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Deleted in Colorectal Carcinoma (DCC) (Internal Region) antibodyDCC 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Deleted in Colorectal Carcinoma (DCC) (AA 1048-1082), (C-Term) antibodyDCC 适用: 人 WB 宿主: 兔 Polyclonal RB51762 unconjugated
anti-Deleted in Colorectal Carcinoma (DCC) (AA 1079-1128) antibodyDCC 适用: 人, 小鼠, 大鼠, 兔, 犬, 豚鼠, 马, 斑马鱼, Pig, 非洲爪蟾 WB 宿主: 兔 Polyclonal unconjugated
anti-Deleted in Colorectal Carcinoma (DCC) (Internal Region) antibodyDCC 适用: 人, 小鼠, 大鼠 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Deleted in Colorectal Carcinoma (DCC) (AA 162-178), (N-Term) antibodyDCC 适用: 人, 小鼠, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Deleted in Colorectal Carcinoma (DCC) (AA 643-670) antibodyDCC 适用: 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB32203 unconjugated
anti-Deleted in Colorectal Carcinoma (DCC) (AA 642-670), (Middle Region) antibodyDCC 适用: 人, 小鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- The stated application concentrations are suggested starting amounts. Titration of the DCC antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL
- 限制
- 仅限研究用
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- 缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
- 储存条件
- -20 °C
- 储存方法
- After reconstitution, the DCC antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
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- 抗原
- DCC (Deleted in Colorectal Carcinoma (DCC))
- 别名
- DCC (DCC 产品)
- 别名
- CRC18 antibody, CRCR1 antibody, IGDCC1 antibody, MRMV1 antibody, DCC antibody, zdcc antibody, C030036D22Rik antibody, Igdcc1 antibody, xdcc antibody, XDCCa antibody, dcca-A antibody, Dcc antibody, DCC netrin 1 receptor antibody, deleted in colorectal carcinoma antibody, netrin receptor DCC antibody, DCC antibody, dcc antibody, Dcc antibody, LOC100712666 antibody
- 背景
- Deleted in Colorectal Carcinoma is also known as CRC18 or CRCR1. The gene encodes a functional receptor for netrin and mediates axon outgrowth and the steering response. Heterozygous loss-of-function mutations in the gene can result in congenital mirror movements. Alterations in DCC occur frequently in colorectal cancer. Studying a YAC contig containing the entire DCC coding region, they showed that the gene spans approximately 1.4 Mb. Vogelstein(1995) stated that the precise location of the gene was thought to be 18q21.3. DCC is a receptor or a component of a receptor that mediates the effects of netrin-1 on commissural axons, and they complement genetic evidence for interactions between DCC and netrin homologs in C. The protein can be detected in varying abundance in all specimens of normal colonic mucosa analyzed as well as in all specimens of adenomatous polyps, colorectal carcinoma and colorectal liver metastases. It may function as a tumor-suppressor protein by inducing apoptosis in settings in which ligand is unavailable (for example, during metastasis or tumor growth beyond local blood supply) through functional caspase cascades by a mechanism that requires cleavage of DCC at asp1290. Stein et al.(2001) concluded that it plays a central role in netrin signaling of axon growth and guidance independent of A2B receptor activation.
- UniProt
- P43146
- 途径
- Regulation of Cell Size
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