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FANCA 抗体 (AA 995-1009)

FANCA 适用: 人, 猴 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN303358
发货至: 中国
  • 抗原 See all FANCA 抗体
    FANCA (Fanconi Anemia Group A Protein (FANCA))
    抗原表位
    • 15
    • 12
    • 7
    • 7
    • 6
    • 6
    • 6
    • 5
    • 5
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 995-1009
    适用
    • 59
    • 18
    • 11
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    人, 猴
    宿主
    • 71
    • 3
    克隆类型
    • 72
    • 2
    多克隆
    标记
    • 32
    • 6
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This FANCA antibody is un-conjugated
    应用范围
    • 36
    • 29
    • 13
    • 13
    • 9
    • 9
    • 9
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    特异性
    This antibody detects Fanconi Anemia Group A Gene (FANCA).
    纯化方法
    Immunoaffinity Chromatography.
    免疫原
    Synthetic peptide corresponding to Amino acids 995-1009 of human FANCA protein.
    Top Product
    Discover our top product FANCA Primary Antibody
  • 应用备注
    Immunohistochemistry on Paraffin Sections (2.5 μg/mL). Immunofluorescence. Western Blot (1/500-1/3000). ELISA (1/15000-1/60000).
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    限制
    仅限研究用
  • 浓度
    1.0 mg/mL
    缓冲液
    0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 with 0.01 % (w/v) Sodium Azide as preservative.
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid cycles of freezing and thawing.
    储存条件
    4 °C/-20 °C
    储存方法
    Store the antibody undiluted at 2-8 °C for one month or at-20 °C for longer. Dilute only prior to immediate use.
  • 抗原
    FANCA (Fanconi Anemia Group A Protein (FANCA))
    别名
    FANCA (FANCA 产品)
    别名
    FA antibody, FA-H antibody, FA1 antibody, FAA antibody, FACA antibody, FAH antibody, FANCH antibody, AW208693 antibody, Fanconi anemia complementation group A antibody, Fanconi anemia, complementation group A antibody, FANCA antibody, Fanca antibody
    背景
    FANCA (also called Protein FACA or Fanconi anemia group A protein) is involved in DNA repair, perhaps specifically with post-replication repair or a cell cycle checkpoint function. FANCA may also be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, and FANCL. The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity, they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group A. Alternative splicing results in multiple transcript variants encoding different isoforms. Variant 1 (isoform a) encodes the longest transcript. Variant 2 (isoform b) contains an alternate exon, which results in an early stop codon, compared to variant 1. Isoform b has a shorter C-terminus when compared to isoform a. Mutations in this gene are the most common cause of Fanconi anemia.Synonyms: FAA, FACA, FANCH, Fanconi anemia group A protein
    基因ID
    2175
    NCBI登录号
    NP_000126
    UniProt
    O15360
    途径
    DNA Damage Repair
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