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MAP2K3 抗体 (N-Term)

This anti-MAP2K3 antibody is a 兔 多克隆 antibody detecting MAP2K3 in WB. Suitable for 人, 小鼠 和 大鼠.
产品编号 ABIN3031842
发货至: 中国

Quick Overview for MAP2K3 抗体 (N-Term) (ABIN3031842)

抗原

See all MAP2K3 抗体
MAP2K3 (Mitogen-Activated Protein Kinase Kinase 3 (MAP2K3))

适用

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人, 小鼠, 大鼠

宿主

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克隆类型

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多克隆

标记

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This MAP2K3 antibody is un-conjugated

应用范围

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Western Blotting (WB)
  • 抗原表位

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    N-Term

    纯化方法

    Antigen affinity

    免疫原

    An amino acid sequence from the N-terminus of human MEK3 (RNLDSRTFITIGDRNFE) was used as the immunogen for this MEK3 antibody (100% homologous in human, mouse and rat).

    亚型

    IgG
  • 应用备注

    The stated application concentrations are suggested starting amounts. Titration of the MEK3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL

    限制

    仅限研究用
  • 缓冲液

    0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

    储存条件

    -20 °C

    储存方法

    After reconstitution, the MEK3 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
  • 抗原

    MAP2K3 (Mitogen-Activated Protein Kinase Kinase 3 (MAP2K3))

    别名

    MEK3

    背景

    Dual specificity mitogen-activated protein kinase kinase 3 is an enzyme that in humans is encoded by the MAP2K3 gene. The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. Rampoldi et al.(1997) localized the MAP2K3 gene to 17q11.2.

    UniProt

    P46734

    途径

    MAPK Pathway, TLR signaling, Activation of Innate immune Response, Toll-Like Receptors Cascades, Autophagy, Signaling Events mediated by VEGFR1 and VEGFR2
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