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Dual Specificity Phosphatase 3 (DUSP3) (C-Term) 抗体

DUSP3 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN3030775
发货至: 中国
  • 抗原 See all Dual Specificity Phosphatase 3 (DUSP3) 抗体
    Dual Specificity Phosphatase 3 (DUSP3)
    抗原表位
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    C-Term
    适用
    • 40
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    人, 小鼠, 大鼠
    宿主
    • 51
    • 7
    克隆类型
    • 51
    • 7
    多克隆
    标记
    • 26
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    非结合性
    应用范围
    • 40
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    Western Blotting (WB)
    纯化方法
    Antigen affinity
    免疫原
    An amino acid sequence from the C-terminus of human DUSP3(RQNREIGPNDGFLAQLC) was used as the immunogen for this DUSP3 antibody (100% homologous in human, mouse and rat).
    亚型
    IgG
    Top Product
    Discover our top product DUSP3 Primary Antibody
  • 应用备注
    The stated application concentrations are suggested starting amounts. Titration of the DUSP3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL
    限制
    仅限研究用
  • 缓冲液
    0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
    储存条件
    -20 °C
    储存方法
    After reconstitution, the DUSP3 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
  • 抗原
    Dual Specificity Phosphatase 3 (DUSP3)
    别名
    DUSP3 (DUSP3 产品)
    别名
    dusp3 antibody, si:bz18k17.3 antibody, si:rp71-18k17.3 antibody, VHR antibody, RGD1560049 antibody, 2210015O03Rik antibody, 5031436O03Rik antibody, T-DSP11 antibody, dual specificity phosphatase 3 antibody, dual specificity phosphatase 3b antibody, dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related) antibody, DUSP3 antibody, dusp3b antibody, Dusp3 antibody
    物质类
    Viral Protein
    背景
    Dual-specificity phosphatase 3, also called VHR, is a member of the dual specificity protein phosphatase subfamily. DUSPs constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. DUSP3 contains the consensus DUSP C-terminal catalytic domain but lacks the N-terminal CH2 domain found in the MKP(mitogen-activated protein kinase phosphatase) class of DUSPs. The DUSP3 gene is mapped on 17q21.31. Confocal microscopy demonstrated that phosphorylated VHR accumulated at the immune synapse between the T cell and the antigen-presenting cell in the presence of antigen. Tyrosine phosphorylation of VHR affects protein-protein interaction, subcellular location, or substrate targeting, given that tyr138 is located on the opposite side of the VHR catalytic center.
    UniProt
    P51452
    途径
    Neurotrophin Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades
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