TP53BP1 抗体 (C-Term)
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- 抗原 See all TP53BP1 抗体
- TP53BP1 (Tumor Protein P53 Binding Protein 1 (TP53BP1))
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抗原表位
- C-Term
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适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This TP53BP1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- 纯化方法
- Antigen affinity
- 免疫原
- An amino acid sequence from the C-terminus of human 53BP1 (ERIGFKQHPKYKHDYVSH) was used as the immunogen for this 53BP1 antibody (100% mouse homology).
- 亚型
- IgG
- Top Product
- Discover our top product TP53BP1 Primary Antibody
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anti-Tumor Protein P53 Binding Protein 1 (TP53BP1) (AA 574-773) antibody
TP53BP1 适用: 人 WB, IHC, ELISA, FACS 宿主: 小鼠 Monoclonal 6B3E10 unconjugated
anti-Tumor Protein P53 Binding Protein 1 (TP53BP1) antibodyTP53BP1 适用: 人 WB, IF, ICC, IP, FACS 宿主: 兔 Polyclonal unconjugated
anti-Tumor Protein P53 Binding Protein 1 (TP53BP1) (N-Term) antibodyKO Validated TP53BP1 适用: 人 WB, IF, ICC, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Tumor Protein P53 Binding Protein 1 (TP53BP1) (AA 1955-1972), (C-Term) antibodyTP53BP1 适用: 人, 小鼠, 大鼠 WB, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Tumor Protein P53 Binding Protein 1 (TP53BP1) (pSer25), (pSer29) antibodyTP53BP1 适用: 人, 小鼠, 大鼠 ELISA, ICC, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Tumor Protein P53 Binding Protein 1 (TP53BP1) (N-Term) antibodyTP53BP1 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Tumor Protein P53 Binding Protein 1 (TP53BP1) (AA 1763-1977) antibodyTP53BP1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Tumor Protein P53 Binding Protein 1 (TP53BP1) (pSer25) antibodyTP53BP1 适用: 人 IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Tumor Protein P53 Binding Protein 1 (TP53BP1) (pThr543) antibodyTP53BP1 适用: 人, 猴 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Tumor Protein P53 Binding Protein 1 (TP53BP1) (N-Term) antibodyTP53BP1 适用: 人, 小鼠, 大鼠 WB, IHC, IF, IC 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- The stated application concentrations are suggested starting points. Titration of the 53BP1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL,Immunocytochemistry: 0.5-1 μg/mL
- 限制
- 仅限研究用
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- 缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
- 储存条件
- -20 °C
- 储存方法
- After reconstitution, the 53BP1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
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- 抗原
- TP53BP1 (Tumor Protein P53 Binding Protein 1 (TP53BP1))
- 别名
- 53BP1 (TP53BP1 产品)
- 别名
- TP53BP1 antibody, MGC160112 antibody, 53BP1 antibody, Tp53bp1 antibody, m53BP1 antibody, p202 antibody, Trp53bp1 antibody, tumor protein p53 binding protein 1 antibody, tumor suppressor p53-binding protein 1 antibody, tumor protein p53 binding protein 1 (predicted), 5 prime antibody, transformation related protein 53 binding protein 1 antibody, TP53BP1 antibody, tp53bp1 antibody, LOC100550605 antibody, Trp53bp1 antibody, Tp53bp1 antibody
- 背景
- Tumor Protein p53-Binding Protein 1, also called 53BP1, is a protein that in humans is encoded by the TP53BP1 gene. Iwabuchi et al.(1998) mapped the gene to 15q15-q21 by FISH. Iwabuchi et al.(1994) showed that TP53BP1 binds to the conformationally sensitive central domain of wildtype p53 but not to mutant p53 in vitro. Immunoblot analysis by Iwabuchi et al.(1998) showed that expression of TP53BP1 or TP53BP2 enhances the transactivation function of p53 and induces the expression of p21(CDKN1A). Wang et al.(2002) used small interfering RNA directed against the protein in mammalian cells to demonstrate that TP53BP1 is a key transducer of the DNA damage checkpoint signal. It was required for p53 accumulation, G2/M checkpoint arrest, and the intra-S-phase checkpoint in response to ionizing radiation.
- UniProt
- Q12888
- 途径
- DNA Damage Repair
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