HSPG2 抗体
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- 抗原 See all HSPG2 抗体
- HSPG2 (Heparan Sulfate Proteoglycan 2 (HSPG2))
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适用
- 人, 小鼠, Cow, 鱼, 猴, Pig
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宿主
- 大鼠
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克隆类型
- 单克隆
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标记
- This HSPG2 antibody is un-conjugated
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应用范围
- Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF), Flow Cytometry (FACS)
- 产品特性
- This mAb specifically precipitates heterogeneous material of high MW, identified as perlecan, a major heparan-sulfate proteoglycan (HSPG) within all basement membranes and cell surfaces. It does not cross-react with laminin, fibronectin, or dermatran sulfate proteoglycan. Because of perlecan s strategic location and ability to store and protect growth factors, it has been strongly implicated in the control of tumor cell growth and metastatic behavior. Perlecan possesses angiogenic and growth-promoting attributes primarily by acting as a co-receptor for basic fibroblast growth factor (FGF-2). Suppression of perlecan causes substantial inhibition of neoplastic growth and neovascularization. Thus, perlecan is a potent inducer of neoplasm growth and angiogenesis in vivo and therapeutic interventions targeting this key modulator of tumor progression may improve neoplastic treatment.
- 纯化方法
- Protein G affinity chromatography
- 免疫原
- A murine EHS laminin preparation was used as the immunogen for the anti-Perlecan antibody.
- 克隆位点
- SPM255
- 亚型
- IgG2a kappa
- Top Product
- Discover our top product HSPG2 Primary Antibody
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anti-Heparan Sulfate Proteoglycan 2 (HSPG2) (AA 4149-4391) antibody
HSPG2 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Heparan Sulfate Proteoglycan 2 (HSPG2) antibodyHSPG2 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Heparan Sulfate Proteoglycan 2 (HSPG2) antibodyHSPG2 适用: 人, 小鼠 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Heparan Sulfate Proteoglycan 2 (HSPG2) antibodyHSPG2 适用: 人, 小鼠, Cow, 鱼, 猴, Pig IHC, IF, FACS, ISt, StM 宿主: 大鼠 Monoclonal A7L6 unconjugated
anti-Heparan Sulfate Proteoglycan 2 (HSPG2) antibodyHSPG2 适用: 人, Cow WB, IHC, ELISA, IP, IHC (p), IHC (fro) 宿主: 小鼠 Monoclonal A71 unconjugated
anti-Heparan Sulfate Proteoglycan 2 (HSPG2) antibodyHSPG2 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Heparan Sulfate Proteoglycan 2 (HSPG2) (AA 25-134) antibodyHSPG2 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Heparan Sulfate Proteoglycan 2 (HSPG2) (Domain 4) antibodyHSPG2 适用: 人, 小鼠, Cow, 大鼠 WB, IHC, IP, ICC, IHC (fro) 宿主: 大鼠 Monoclonal A7L6 unconjugated
anti-Heparan Sulfate Proteoglycan 2 (HSPG2) antibodyHSPG2 适用: 人 WB, IP, ICC, IHC (fro) 宿主: 大鼠 Monoclonal A7L6 unconjugated
anti-Heparan Sulfate Proteoglycan 2 (HSPG2) (AA 524-701) antibodyHSPG2 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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Optimal dilution of the anti-Perlecan antibody should be determined by the researcher.
1. Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM Citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 min
2. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.\. Flow Cytometry: 0.5-1 μg/million cells in 0.1ml,Immunofluorescence: 0.5-1 μg/mL,Immunohistochemistry (FFPE): 1-2 μg/mL for 30 min at RT (1),Prediluted format : incubate for 30 min at RT (2) - 限制
- 仅限研究用
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- 浓度
- 0.2 mg/mL
- 缓冲液
- 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Store the anti-Perlecan antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).
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- 抗原
- HSPG2 (Heparan Sulfate Proteoglycan 2 (HSPG2))
- 别名
- Perlecan (HSPG) (HSPG2 产品)
- 别名
- HSPG antibody, PLC antibody, PRCAN antibody, SJA antibody, SJS antibody, SJS1 antibody, HSPG2 antibody, AI852380 antibody, Pcn antibody, Plc antibody, per antibody, Per antibody, heparan sulfate proteoglycan 2 antibody, perlecan (heparan sulfate proteoglycan 2) antibody, HSPG2 antibody, hspg2 antibody, Hspg2 antibody
- 背景
- This mAb specifically precipitates heterogeneous material of high MW, identified as perlecan, a major heparan-sulfate proteoglycan (HSPG) within all basement membranes and cell surfaces. It does not cross-react with laminin, fibronectin, or dermatran sulfate proteoglycan. Because of perlecan s strategic location and ability to store and protect growth factors, it has been strongly implicated in the control of tumor cell growth and metastatic behavior. Perlecan possesses angiogenic and growth-promoting attributes primarily by acting as a co-receptor for basic fibroblast growth factor (FGF-2). Suppression of perlecan causes substantial inhibition of neoplastic growth and neovascularization. Thus, perlecan is a potent inducer of neoplasm growth and angiogenesis in vivo and therapeutic interventions targeting this key modulator of tumor progression may improve neoplastic treatment.
- 途径
- Glycosaminoglycan Metabolic Process, Lipid Metabolism
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