HSPG2 产品
(Heparan Sulfate Proteoglycan 2 (HSPG2))
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This gene encodes the perlecan protein, which consists of a core protein to which three long chains of glycosaminoglycans (heparan sulfate or chondroitin sulfate) are attached. The perlecan protein is a large multidomain proteoglycan that binds to and cross-links many extracellular matrix components and cell-surface molecules. It has been shown that this protein interacts with laminin, prolargin, collagen type IV, FGFBP1, FBLN2, FGF7 and Transthyretin, etc. and plays essential roles in multiple biological activities. Perlecan is a key component of the vascular extracellular matrix, where it helps to maintain the endothelial barrier function. It is a potent inhibitor of smooth muscle cell proliferation and is thus thought to help maintain vascular homeostasis. It can also promote growth factor (e.g., FGF2) activity and thus stimulate endothelial growth and re-generation. It is a major component of basement membranes, where it is involved in the stabilization of other molecules as well as being involved with glomerular permeability to macromolecules and cell adhesion. Mutations in this gene cause Schwartz-Jampel syndrome type 1, Silverman-Handmaker type of dyssegmental dysplasia, and Tardive dyskinesia.[provided by RefSeq, Mar 2010].
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Featured HSPG2 Categories
HSPG2 抗体
High quality antibodies with extensive validation data.
HSPG2 ELISA试剂盒
Reliable ELISA kits for a wide range of species.
HSPG2 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended HSPG2 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (12)
Cat. No.
ABIN7435115
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, ELISA
Validations
- (3)
Cat. No.
ABIN7191019
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
IHC, ELISA
Validations
- (2)
Cat. No.
ABIN7243733
Quantity
200 μL
Datasheet
Datasheet
Recommended HSPG2 ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (4)
- (4)
Cat. No.
ABIN6730918
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6956480
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6974795
Quantity
96 tests
Datasheet
Datasheet
Recommended HSPG2 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1307245
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN3094542
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Mouse
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN3134833
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our HSPG2 Products
: "Characterization of Vascular Patterns Associated with Endothelial Glycocalyx Damage in Early- and Late-Onset Preeclampsia." in: Biomedicines, Vol. 10, Issue 11, (2022) (PubMed).: "Expression and Circulating Levels of Perlecan in Breast Cancer - Implications for Oestrogen Dependent Stromal Remodeling." in: Journal of mammary gland biology and neoplasia, Vol. 25, Issue 1, pp. 69-77, (2020) (PubMed).
: "Dynamic Assembly of Human Salivary Stem/Progenitor Microstructures Requires Coordinated α1β1 Integrin-Mediated Motility." in: Frontiers in cell and developmental biology, Vol. 7, pp. 224, (2019) (PubMed).
: "Key Matrix Proteins Within the Pancreatic Islet Basement Membrane Are Differentially Digested During Human Islet Isolation." in: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, Vol. 17, Issue 2, pp. 451-461, (2016) (PubMed).
: "Suramin inhibits hepatic tissue damage in hepatocellular carcinoma through deactivation of heparanase enzyme." in: European journal of pharmacology, Vol. 728, pp. 151-60, (2014) (PubMed).
: "Proteomics of Follicular Fluid from Women with Polycystic Ovary Syndrome Suggests Molecular Defects in Follicular Development." in: The Journal of clinical endocrinology and metabolism, pp. jc20142086, (2014) (PubMed).
Synonyms and alternative names related to HSPG2
heparan sulfate proteoglycan 2 (HSPG2), heparan sulfate proteoglycan 2 (hspg2), perlecan (heparan sulfate proteoglycan 2) (Hspg2), heparan sulfate proteoglycan 2 (Hspg2), AI852380, HSPG, HSPG2, Pcn, per, Per, PLC, Plc, PRCAN, SJA, SJS, SJS1Protein level used designations for HSPG2
- basement membrane-specific heparan sulfate proteoglycan core protein
- endorepellin (domain V region)
- perlecan proteoglycan
- heparan sulfate proteoglycan 2
- perlecan
- basement membrane-specific heparan sulfate proteoglycan core protein-like
- HSPG
- perlecan (heparan sulfate proteoglycan 2)
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