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- 抗原 See all PPP3CA 抗体
- PPP3CA (Protein Phosphatase 3, Catalytic Subunit, alpha Isoform (PPP3CA))
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抗原表位
- AA 1-511
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This PPP3CA antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunofluorescence (IF)
- 序列
- MSEPKAIDPK LSTTDRVVKA VPFPPSHRLT AKEVFDNDGK PRVDILKAHL MKEGRLEESV ALRIITEGAS ILRQEKNLLD IDAPVTVCGD IHGQFFDLMK LFEVGGSPAN TRYLFLGDYV DRGYFSIECV LYLWALKILY PKTLFLLRGN HECRHLTEYF TFKQECKIKY SERVYDACMD AFDCLPLAAL MNQQFLCVHG GLSPEINTLD DIRKLDRFKE PPAYGPMCDI LWSDPLEDFG NEKTQEHFTH NTVRGCSYFY SYPAVCEFLQ HNNLLSILRA HEAQDAGYRM YRKSQTTGFP SLITIFSAPN YLDVYNNKAA VLKYENNVMN IRQFNCSPHP YWLPNFMDVF TWSLPFVGEK VTEMLVNVLN ICSDDELGSE EDGFDGATAA ARKEVIRNKI RAIGKMARVF SVLREESESV LTLKGLTPTG MLPSGVLSGG KQTLQSAIKG FSPQHKITSF EEAKGLDRIN ERMPPRRDAM PSDANLNSIN KALTSETNGT DSNGSNSSNI Q
- 交叉反应
- 人, 小鼠
- 产品特性
- Polyclonal Antibodies
- 免疫原
- Recombinant fusion protein containing a sequence corresponding to amino acids 1-511 of human Calcineurin A (NP_001124163.1).
- 亚型
- IgG
- Top Product
- Discover our top product PPP3CA Primary Antibody
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- 应用备注
- WB,1:500 - 1:2000,IF,1:50 - 1:200
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid freeze / thaw cycles
- 储存条件
- -20 °C
- 储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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Fasting-induced hormonal regulation of lysosomal function." in: Cell research, Vol. 27, Issue 6, pp. 748-763, (2018) (PubMed).
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Fasting-induced hormonal regulation of lysosomal function." in: Cell research, Vol. 27, Issue 6, pp. 748-763, (2018) (PubMed).
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- 抗原
- PPP3CA (Protein Phosphatase 3, Catalytic Subunit, alpha Isoform (PPP3CA))
- 别名
- PPP3CA (PPP3CA 产品)
- 别名
- CALN antibody, CALNA antibody, CALNA1 antibody, CCN1 antibody, CNA1 antibody, PPP2B antibody, 2900074D19Rik antibody, AI841391 antibody, AW413465 antibody, CN antibody, Caln antibody, Calna antibody, CnA antibody, Calna1 antibody, calcineurin antibody, caln antibody, calna antibody, calna1 antibody, ccn1 antibody, cna1 antibody, ppp2b antibody, fj46e08 antibody, si:dkeyp-79c2.2 antibody, wu:fj46e08 antibody, ppp3ca antibody, protein phosphatase 3 catalytic subunit alpha antibody, protein phosphatase 3, catalytic subunit, alpha isoform antibody, protein phosphatase 3, catalytic subunit, alpha isozyme antibody, protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform (calcineurin A alpha) antibody, protein phosphatase 3, catalytic subunit, alpha isozyme L homeolog antibody, serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform antibody, PPP3CA antibody, Ppp3ca antibody, ppp3ca antibody, ppp3ca.L antibody, LOC100205420 antibody
- 背景
- Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+-mediated signals. Many of the substrates contain a PxIxIT motif and/or a LxVP motif. In response to increased Ca(2+ levels, dephosphorylates and activates phosphatase SSH1 which results in cofilin dephosphorylation. In response to increased Ca(2+ levels following mitochondrial depolarization, dephosphorylates DNM1L inducing DNM1L translocation to the mitochondrion. Dephosphorylates heat shock protein HSPB1 (By similarity. Dephosphorylates and activates transcription factor NFATC1. In response to increased Ca(2+ levels, regulates NFAT-mediated transcription probably by dephosphorylating NFAT and promoting its nuclear translocation. Dephosphorylates and inactivates transcription factor ELK1. Dephosphorylates DARPP32. May dephosphorylate CRTC2 at 'Ser-171' resulting in CRTC2 dissociation from 14-3-3 proteins. Dephosphorylates transcription factor TFEB at 'Ser-211' following Coxsackievirus B3 infection, promoting nuclear translocation.,PPP3CA,CALN,CALNA,CALNA1,CCN1,CNA1,PPP2B,Signal Transduction,ErbB-HER Signaling Pathway,Cell Biology & Developmental Biology,Cytoskeleton,Actins,Immunology & Inflammation,B Cell Receptor Signaling Pathway,T Cell Receptor Signaling Pathway,Neuroscience,Calcium Signaling,Neurodegenerative Diseases,PPP3CA
- 分子量
- 31 kDa/51 kDa/52 kDa/57 kDa/58 kDa
- 基因ID
- 5530
- UniProt
- Q08209
- 途径
- RTK signaling, WNT signaling, Fc-epsilon Receptor Signaling Pathway, Negative Regulation of Hormone Secretion, Carbohydrate Homeostasis, Synaptic Membrane, Skeletal Muscle Fiber Development, Protein targeting to Nucleus, VEGF Signaling, BCR Signaling
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