LIM Domain Kinase 1 抗体 (pThr508)
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- 抗原 See all LIM Domain Kinase 1 (LIMK1) 抗体
- LIM Domain Kinase 1 (LIMK1)
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抗原表位
- pThr508
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This LIM Domain Kinase 1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
- 交叉反应
- 人, 小鼠, 大鼠
- 产品特性
- Phosphorylated Antibodies
- 免疫原
- A phospho specific peptide corresponding to residues surrounding T508 of human LIMK1
- 亚型
- IgG
- Top Product
- Discover our top product LIMK1 Primary Antibody
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- 应用备注
- WB,1:500 - 1:2000,IHC,1:50 - 1:100,IF,1:100 - 1:200
- 限制
- 仅限研究用
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- 缓冲液
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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- 抗原
- LIM Domain Kinase 1 (LIMK1)
- 别名
- LIMK1 (LIMK1 产品)
- 别名
- limk1 antibody, xlimk1 antibody, GB16654 antibody, LIMK1 antibody, LIMK antibody, LIMK-1 antibody, LIM domain kinase 1 antibody, LIM domain kinase 1a antibody, LIM domain kinase 1 L homeolog antibody, LIM-domain containing, protein kinase antibody, LIMK1 antibody, limk1a antibody, limk1 antibody, CpipJ_CPIJ000717 antibody, LOC413152 antibody, Limk1 antibody, limk1.L antibody
- 背景
- There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is a serine/threonine kinase that regulates actin polymerization via phosphorylation and inactivation of the actin binding factor cofilin. This protein is ubiquitously expressed during development and plays a role in many cellular processes associated with cytoskeletal structure. This protein also stimulates axon growth and may play a role in brain development. LIMK1 hemizygosity is implicated in the impaired visuospatial constructive cognition of Williams syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.,LIMK1,LIMK,LIMK-1,Signal Transduction,Kinase,Serine/threonine kinases,Tyrosine kinases,Cell Biology & Developmental Biology,Cytoskeleton,Microfilaments,Microtubules,Actins,TGF-b-Smad Signaling Pathway,Immunology & Inflammation,Neuroscience,Cell Type Marker,Neuron marker,Growth Cone,Protein phosphorylation,LIMK1
- 分子量
- 33 kDa/68 kDa/70 kDa/72 kDa
- 基因ID
- 3984
- UniProt
- P53667
- 途径
- Caspase Cascade in Apoptosis, Regulation of Cell Size, CXCR4-mediated Signaling Events
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