HLA-DMA 抗体 (N-Term)
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- 抗原 See all HLA-DMA 抗体
- HLA-DMA (Major Histocompatibility Complex, Class II, DM alpha (HLA-DMA))
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抗原表位
- N-Term
- 适用
- 人, 大鼠, 兔, 犬
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This HLA-DMA antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 序列
- GLSEAYDEDQ LFFFDFSQNT RVPRLPEFAD WAQEQGDAPA ILFDKEFCEW
- 预测反应
- Dog: 77%, Human: 100%, Rabbit: 82%, Rat: 86%
- 产品特性
- This is a rabbit polyclonal antibody against HLA-DMA. It was validated on Western Blot.
- 纯化方法
- Affinity Purified
- 免疫原
- The immunogen is a synthetic peptide directed towards the N terminal region of human HLA-DMA
- Top Product
- Discover our top product HLA-DMA Primary Antibody
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- 应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
- 说明
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Antigen size: 261 AA
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- Lot specific
- 缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freeze-thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- 抗原
- HLA-DMA (Major Histocompatibility Complex, Class II, DM alpha (HLA-DMA))
- 别名
- HLA-DMA (HLA-DMA 产品)
- 别名
- RT1.Ma antibody, RT1.DMa antibody, HLA-DMA antibody, H-2Ma antibody, H2-Ma antibody, D6S222E antibody, DMA antibody, HLADM antibody, RING6 antibody, RT1 class II, locus DMa antibody, SLA-DM alpha chain antibody, major histocompatibility complex, class II, DM alpha antibody, histocompatibility 2, class II, locus DMa antibody, RT1-DMa antibody, SLA-DMA antibody, DLA-DMA antibody, H2-DMa antibody, HLA-DMA antibody
- 背景
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HLA-DMA belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta chain (DMB), both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail.
Alias Symbols: D6S222E, DMA, HLADM, RING6
Protein Interaction Partner: B3GAT1, U2AF2, RUNX1, UBC, CD82, HLA-DRB1, HLA-DOA, HLA-DRA, HLA-DMB, CD74,
Protein Size: 261 - 分子量
- 29 kDa
- 基因ID
- 3108
- NCBI登录号
- NM_006120, NP_006111
- UniProt
- Q31604
- 途径
- Cancer Immune Checkpoints, Human Leukocyte Antigen (HLA) in Adaptive Immune Response
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