SHC1 抗体 (C-Term)
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- 抗原 See all SHC1 抗体
- SHC1 (SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1))
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抗原表位
- C-Term
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适用
- 人, 小鼠, 大鼠, 犬, Cow, 马, 豚鼠, 兔, 斑马鱼
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This SHC1 antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 序列
- AEQLRGEPWF HGKLSRREAE ALLQLNGDFL VRESTTTPGQ YVLTGLQSGQ
- 预测反应
- Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 93%
- 产品特性
- This is a rabbit polyclonal antibody against SHC1. It was validated on Western Blot using a cell lysate as a positive control.
- 纯化方法
- Affinity Purified
- 免疫原
- The immunogen is a synthetic peptide directed towards the C terminal region of human SHC1
- Top Product
- Discover our top product SHC1 Primary Antibody
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anti-SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1) (AA 171-280) antibody
SHC1 适用: 人 WB, ELISA, IF, IHC (p), PLA 宿主: 小鼠 Monoclonal 3F4 unconjugated
anti-SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1) (AA 385-495) antibodySHC1 适用: 人, 小鼠 WB, ELISA, ICC, FACS 宿主: 小鼠 Monoclonal 2F7C7 unconjugated
anti-SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1) (AA 536-564), (C-Term) antibodySHC1 适用: 人, 小鼠, 大鼠 WB, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1) (AA 424-440), (C-Term) antibodySHC1 适用: 人, 大鼠 WB, IHC (p), ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1) (C-Term) antibodySHC1 适用: 人, 小鼠, 大鼠 WB, IHC (p), ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1) (AA 272-559) antibodySHC1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1) antibodySHC1 适用: 人, 小鼠, 大鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1) (pTyr427) antibodySHC1 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1) (pTyr349) antibodySHC1 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1) (AA 171-280) antibodySHC1 适用: 人 WB, IHC, ELISA, IF, IHC (p), PLA 宿主: 小鼠 Monoclonal 3F4 unconjugated
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- 应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
- 说明
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Antigen size: 474 AA
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- Lot specific
- 缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freeze-thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- 抗原
- SHC1 (SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1))
- 别名
- SHC1 (SHC1 产品)
- 别名
- SHC1 antibody, SHC antibody, SHCA antibody, P66shc antibody, si:dkey-246i14.4 antibody, wu:fc10h03 antibody, shc antibody, p66shc antibody, Shc antibody, ShcA antibody, p66 antibody, SHC adaptor protein 1 antibody, Shc1p antibody, squalene--hopene cyclase antibody, SHC (Src homology 2 domain containing) transforming protein 1 antibody, SHC (Src homology 2 domain containing) transforming protein 1 L homeolog antibody, src homology 2 domain-containing transforming protein C1 antibody, SHC1 antibody, shc1 antibody, Shc1 antibody, shc1.L antibody
- 背景
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SHC1 is a signaling adapter that couples activated growth factor receptors to signaling pathway. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span.
Alias Symbols: FLJ26504, SHC, SHCA, p52SHC, p66, p66SHC
Protein Interaction Partner: GRB2, Socs5, IGF1R, UBC, EGFR, Hgf, GAB2, GAB1, CBL, ERBB4, ERBB3, ERBB2, NEDD8, ZAP70, DOK1, KRT77, TUBB2B, TUBB, EEF1A1P5, ARAP1, TIMM50, UBASH3B, TUBA1C, PPP1R9B, TUBB6, ATAD3B, TUBA4B, TUBAL3, MYH14, LRRK1, TUBA8, RAB3GAP2, CORO1C, RUVBL2, CCT2, HAX1,
Protein Size: 474 - 分子量
- 52 kDa
- 基因ID
- 6464
- NCBI登录号
- NM_003029, NP_003020
- UniProt
- P29353
- 途径
- RTK signaling, TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, ER-Nucleus Signaling, Signaling Events mediated by VEGFR1 and VEGFR2
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