PTPN1 抗体 (Middle Region)
-
- 抗原 See all PTPN1 抗体
- PTPN1 (Protein tyrosine Phosphatase, Non-Receptor Type 1 (PTPN1))
-
抗原表位
- Middle Region
-
适用
- 人, 小鼠, 大鼠, 斑马鱼, 犬, 马, 豚鼠, Cow, 兔
-
宿主
- 兔
-
克隆类型
- 多克隆
-
标记
- This PTPN1 antibody is un-conjugated
-
应用范围
- Western Blotting (WB)
- 序列
- SGSLSPEHGP VVVHCSAGIG RSGTFCLADT CLLLMDKRKD PSSVDIKKVL
- 预测反应
- Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 93%, Rat: 100%, Zebrafish: 79%
- 产品特性
- This is a rabbit polyclonal antibody against PTPN1. It was validated on Western Blot using a cell lysate as a positive control.
- 纯化方法
- Affinity Purified
- 免疫原
- The immunogen is a synthetic peptide directed towards the middle region of human PTPN1
- Top Product
- Discover our top product PTPN1 Primary Antibody
-
anti-Protein tyrosine Phosphatase, Non-Receptor Type 1 (PTPN1) antibody
PTPN1 适用: 人, 猴, 犬 WB, IHC, FACS, IF, IHC (p) 宿主: 小鼠 Monoclonal 1D10 unconjugated
anti-Protein tyrosine Phosphatase, Non-Receptor Type 1 (PTPN1) (AA 40-246) antibodyPTPN1 适用: 人 WB, ELISA, IHC, FACS, ICC 宿主: 小鼠 Monoclonal 4F8F11 unconjugated
anti-Protein tyrosine Phosphatase, Non-Receptor Type 1 (PTPN1) (AA 1-100) antibodyPTPN1 适用: 人, 小鼠, 大鼠 WB, ELISA, FACS, IHC (p), IF (cc), IF (p), ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Protein tyrosine Phosphatase, Non-Receptor Type 1 (PTPN1) antibodyKO Validated PTPN1 适用: 人, 小鼠, 大鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Protein tyrosine Phosphatase, Non-Receptor Type 1 (PTPN1) (pSer50) antibodyPTPN1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Protein tyrosine Phosphatase, Non-Receptor Type 1 (PTPN1) antibodyPTPN1 适用: 人 WB, ELISA, IHC 宿主: 兔 Monoclonal 1G3 unconjugated Recombinant Antibody
anti-Protein tyrosine Phosphatase, Non-Receptor Type 1 (PTPN1) (N-Term) antibodyPTPN1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Protein tyrosine Phosphatase, Non-Receptor Type 1 (PTPN1) (AA 268-406) antibodyPTPN1 适用: 人 WB, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Protein tyrosine Phosphatase, Non-Receptor Type 1 (PTPN1) (AA 40-246) antibodyPTPN1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 4F8F2 unconjugated
anti-Protein tyrosine Phosphatase, Non-Receptor Type 1 (PTPN1) (AA 23-53), (N-Term) antibodyPTPN1 适用: 人 WB 宿主: 兔 Polyclonal RB7011 unconjugated
-
- 应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
- 说明
-
Antigen size: 435 AA
- 限制
- 仅限研究用
-
- 状态
- Liquid
- 浓度
- Lot specific
- 缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freeze-thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
-
- 抗原
- PTPN1 (Protein tyrosine Phosphatase, Non-Receptor Type 1 (PTPN1))
- 别名
- PTPN1 (PTPN1 产品)
- 别名
- PTPN1 antibody, PTP1B antibody, PTP-1B antibody, PTP-HA2 antibody, Ptp antibody, ptp1b antibody, wu:fk54h03 antibody, CPTP1 antibody, protein tyrosine phosphatase, non-receptor type 1 antibody, protein tyrosine phosphatase, non-receptor type 1 L homeolog antibody, PTPN1 antibody, Ptpn1 antibody, ptpn1 antibody, ptpn1.L antibody
- 背景
-
PTPN1 is the founding member of the protein tyrosine phosphatase (PTP) family. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation.The protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: PTP1B
Protein Interaction Partner: IL1B, RFWD2, UBC, SUMO1, NEDD8, ATP4A, SRC, CSNK2A1, STAT3, JAK2, ATF2, ASS1, Dlg4, MARCKSL1, MCAT, ZMPSTE24, LAMTOR3, SLC25A3, ILF3, HNRNPU, STAM2, GHR, PIAS1, CLK1, TRPV6, GSK3B, STAT5B, CLK2, BCAR1, LAT, STAT5A, PIN1, CAV1, NTRK2, GLRX, RRAS2, NTRK3, N
Protein Size: 435 - 分子量
- 50 kDa
- 基因ID
- 5770
- NCBI登录号
- NM_002827, NP_002818
- UniProt
- P18031
- 途径
- TLR signaling, Response to Growth Hormone Stimulus, ER-Nucleus Signaling, Platelet-derived growth Factor Receptor Signaling
-
