(6 references)-
- 抗原 See all PTPN1 抗体
- PTPN1 (Protein tyrosine Phosphatase, Non-Receptor Type 1 (PTPN1))
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抗原表位
- AA 23-53, N-Term
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This PTPN1 antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 预测反应
- M, Rat
- 纯化方法
- This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
- 免疫原
- This PTP1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 23-53 amino acids from the N-terminal region of human PTP1B.
- 克隆位点
- RB7011
- 亚型
- Ig Fraction
- Top Product
- Discover our top product PTPN1 Primary Antibody
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anti-Protein tyrosine Phosphatase, Non-Receptor Type 1 (PTPN1) antibody
PTPN1 适用: 人, 猴, 犬 WB, IHC, FACS, IF, IHC (p) 宿主: 小鼠 Monoclonal 1D10 unconjugated
anti-Protein tyrosine Phosphatase, Non-Receptor Type 1 (PTPN1) (AA 40-246) antibodyPTPN1 适用: 人 WB, ELISA, IHC, FACS, ICC 宿主: 小鼠 Monoclonal 4F8F11 unconjugated
anti-Protein tyrosine Phosphatase, Non-Receptor Type 1 (PTPN1) (AA 1-100) antibodyPTPN1 适用: 人, 小鼠, 大鼠 WB, ELISA, FACS, IHC (p), IF (cc), IF (p), ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Protein tyrosine Phosphatase, Non-Receptor Type 1 (PTPN1) antibodyKO Validated PTPN1 适用: 人, 小鼠, 大鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Protein tyrosine Phosphatase, Non-Receptor Type 1 (PTPN1) (pSer50) antibodyPTPN1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Protein tyrosine Phosphatase, Non-Receptor Type 1 (PTPN1) antibodyPTPN1 适用: 人 WB, ELISA, IHC 宿主: 兔 Monoclonal 1G3 unconjugated Recombinant Antibody
anti-Protein tyrosine Phosphatase, Non-Receptor Type 1 (PTPN1) (N-Term) antibodyPTPN1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Protein tyrosine Phosphatase, Non-Receptor Type 1 (PTPN1) (AA 268-406) antibodyPTPN1 适用: 人 WB, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Protein tyrosine Phosphatase, Non-Receptor Type 1 (PTPN1) (AA 40-246) antibodyPTPN1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 4F8F2 unconjugated
anti-Protein tyrosine Phosphatase, Non-Receptor Type 1 (PTPN1) (AA 221-249) antibodyPTPN1 适用: 小鼠 WB 宿主: 兔 Polyclonal RB41801 unconjugated
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- 应用备注
- WB: 1:1000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 有效期
- 6 months
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: "Calpain-mediated degradation of reversibly oxidized protein-tyrosine phosphatase 1B." in: The FEBS journal, Vol. 276, Issue 19, pp. 5622-33, (2009) (PubMed).
: "Reduction of PTP1B by RNAi upregulates the activity of insulin controlled fatty acid synthase promoter." in: Biochemical and biophysical research communications, Vol. 329, Issue 2, pp. 538-43, (2005) (PubMed).
: "Pharmacokinetic distribution of 67Cu(II)2[3,5-diisopropyl(carboxy-14C)salicylate]4 among murine tissues." in: Current medicinal chemistry, Vol. 11, Issue 22, pp. 3007-15, (2004) (PubMed).
: "Allosteric inhibition of protein tyrosine phosphatase 1B." in: Nature structural & molecular biology, Vol. 11, Issue 8, pp. 730-7, (2004) (PubMed).
: "Single nucleotide polymorphisms of protein tyrosine phosphatase 1B gene are associated with obesity in morbidly obese French subjects." in: Diabetologia, Vol. 47, Issue 7, pp. 1278-84, (2004) (PubMed).
: "Association of protein tyrosine phosphatase 1B gene polymorphisms with measures of glucose homeostasis in Hispanic Americans: the insulin resistance atherosclerosis study (IRAS) family study." in: Diabetes, Vol. 53, Issue 11, pp. 3013-9, (2004) (PubMed).
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: "Calpain-mediated degradation of reversibly oxidized protein-tyrosine phosphatase 1B." in: The FEBS journal, Vol. 276, Issue 19, pp. 5622-33, (2009) (PubMed).
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- 抗原
- PTPN1 (Protein tyrosine Phosphatase, Non-Receptor Type 1 (PTPN1))
- 别名
- PTP1B (PTPN1 产品)
- 别名
- PTPN1 antibody, PTP1B antibody, PTP-1B antibody, PTP-HA2 antibody, Ptp antibody, ptp1b antibody, wu:fk54h03 antibody, CPTP1 antibody, protein tyrosine phosphatase, non-receptor type 1 antibody, protein tyrosine phosphatase, non-receptor type 1 L homeolog antibody, PTPN1 antibody, Ptpn1 antibody, ptpn1 antibody, ptpn1.L antibody
- 背景
- PTP1B is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation.
- 分子量
- 49967
- NCBI登录号
- NP_001265547, NP_002818
- UniProt
- P18031
- 途径
- TLR signaling, Response to Growth Hormone Stimulus, ER-Nucleus Signaling, Platelet-derived growth Factor Receptor Signaling
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