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CD40 抗体 (N-Term)

Name: CD40 抗体 (N-Term)
SKU: ABIN2777069
Availability: OutOfStock

CD40 适用: 人, 兔 WB 宿主: 兔 Polyclonal unconjugated

WB Suggested Anti-CD40 Antibody Titration: 0. (CD40 抗体 (N-Term))

1 image

产品编号 ABIN2777069

发货至: 中国

Datasheet as PDF

抗原 See all CD40 抗体

CD40
抗原表位
17

16

14

13

13

11

9

5

5

4

3

3

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
N-Term
适用
187

97

20

19

7

6

4

4

4

4

2

2

2

2

2

1

1
人, 兔
宿主
103

99

43

3

1

1

1
兔
Compatible Secondaries
克隆类型
156

88

5
多克隆
标记
118

22

20

20

12

6

5

4

3

3

3

3

3

3

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
This CD40 antibody is un-conjugated
应用范围
145

91

62

50

30

28

19

18

17

14

13

13

5

4

4

4

3

3

3

3

3

2

2

2

2

2

1

1
Western Blotting (WB)

序列

WNRETHCHQH KYCDPNLGLR VQQKGTSETD TICTCEEGWH CTSEACESCV

预测反应

Human: 100%, Rabbit: 79%

产品特性

This is a rabbit polyclonal antibody against CD40. It was validated on Western Blot using a cell lysate as a positive control.

纯化方法

Affinity Purified

免疫原

The immunogen is a synthetic peptide directed towards the N terminal region of human CD40

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anti-CD40 (CD40) antibody (FITC)
CD40 适用: 人 FACS 宿主: 小鼠 Monoclonal HI40a FITC

应用备注

Optimal working dilutions should be determined experimentally by the investigator.

说明

Antigen size: 277 AA

限制

仅限研究用
状态

Liquid

浓度

Lot specific

缓冲液

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

注意事项

Avoid repeated freeze-thaw cycles.

储存条件

-20 °C

储存方法

For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
抗原

CD40

别名

CD40 (CD40 产品)

别名

Bp50 antibody, CDW40 antibody, TNFRSF5 antibody, p50 antibody, AI326936 antibody, GP39 antibody, HIGM1 antibody, IGM antibody, IMD3 antibody, T-BAM antibody, TRAP antibody, Tnfrsf5 antibody, TNFSF5 antibody, CD40 molecule antibody, CD40 antigen antibody, CD40 antibody, Cd40 antibody

背景

CD40 is a member of the TNF-receptor superfamily. This receptor has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis.The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
Alias Symbols: Bp50, CDW40, MGC9013, TNFRSF5, p50
Protein Interaction Partner: TRAF2, TRAF3, PIK3R1, CD40LG, BAG3, Otud7b, Birc3, IL4R, TRAF6, TRAF5, TRAF3IP2, MAP3K8, TRAF4, TRAF1, PIK3CA, CBL, BIRC2, CDC40, TANK, HSPA4, NSMAF, XRCC5, HSPA8, TDP2, RIPK2, CAV1, JAK3, XRCC6, MS4A1, SUMO1, SLC30A7, RNF219, UGGT1, ERP44, NCOA6, USP15,
Protein Size: 277

分子量

30 kDa

基因ID

958

NCBI登录号

NM_001250, NP_001241

UniProt

P25942

途径

NF-kappaB Signaling, Cellular Response to Molecule of Bacterial Origin, M Phase, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints