SCN5A 抗体 (C-Term)
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- 抗原 See all SCN5A 抗体
- SCN5A (Sodium Channel, Voltage-Gated, Type V, alpha Subunit (SCN5A))
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抗原表位
- C-Term
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适用
- 人, 小鼠, 大鼠, 犬, Cow, 豚鼠, 马, 斑马鱼, 兔
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This SCN5A antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 序列
- FTKRVLGESG EMDALKIQME EKFMAANPSK ISYEPITTTL RRKHEEVSAM
- 预测反应
- Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%
- 产品特性
- This is a rabbit polyclonal antibody against SCN5A. It was validated on Western Blot and immunohistochemistry.
- 纯化方法
- Affinity Purified
- 免疫原
- The immunogen is a synthetic peptide directed towards the C terminal region of human SCN5A
- Top Product
- Discover our top product SCN5A Primary Antibody
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- 应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
- 说明
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Antigen size: 2015 AA
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- Lot specific
- 缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freeze-thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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Similar arrhythmicity in hypertrophic and fibrotic cardiac cultures caused by distinct substrate-specific mechanisms." in: Cardiovascular research, Vol. 97, Issue 1, pp. 171-81, (2012) (PubMed).
: "Optical mapping of cryoinjured rat myocardium grafted with mesenchymal stem cells." in: American journal of physiology. Heart and circulatory physiology, Vol. 302, Issue 1, pp. H270-7, (2011) (PubMed).
: "The histone deacetylase inhibitor suberoylanilide hydroxamic acid reduces cardiac arrhythmias in dystrophic mice." in: Cardiovascular research, Vol. 87, Issue 1, pp. 73-82, (2010) (PubMed).
: "Voltage-gated Na+ channel SCN5A is a key regulator of a gene transcriptional network that controls colon cancer invasion." in: Cancer research, Vol. 70, Issue 17, pp. 6957-67, (2010) (PubMed).
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Similar arrhythmicity in hypertrophic and fibrotic cardiac cultures caused by distinct substrate-specific mechanisms." in: Cardiovascular research, Vol. 97, Issue 1, pp. 171-81, (2012) (PubMed).
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- 抗原
- SCN5A (Sodium Channel, Voltage-Gated, Type V, alpha Subunit (SCN5A))
- 别名
- SCN5A (SCN5A 产品)
- 别名
- Nav1.5 antibody, Nav1.5c antibody, SkM1 antibody, SkM2 antibody, mH1 antibody, CDCD2 antibody, CMD1E antibody, CMPD2 antibody, HB1 antibody, HB2 antibody, HBBD antibody, HH1 antibody, ICCD antibody, IVF antibody, LQT3 antibody, PFHB1 antibody, SSS1 antibody, VF1 antibody, SCAL antibody, sodium voltage-gated channel alpha subunit 5 antibody, sodium channel, voltage-gated, type V, alpha antibody, SCN5A antibody, Scn5a antibody
- 背景
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SCN5A is an integral membrane protein and tetrodotoxin-resistant voltage-gated sodium channel subunit. The protein is found primarily in cardiac muscle and is responsible for the initial upstroke of the action potential in an electrocardiogram.The protein encoded by this gene is an integral membrane protein and tetrodotoxin-resistant voltage-gated sodium channel subunit. The encoded protein is found primarily in cardiac muscle and is responsible for the initial upstroke of the action potential in an electrocardiogram. Defects in this gene are a cause of long QT syndrome type 3 (LQT3), an autosomal dominant cardiac disease. Alternative splicing results in two transcript variants encoding separate isoforms which differ by a single amino acid. Mutation nomenclature has been assigned with respect to the longer isoform.
Alias Symbols: CDCD2, CMD1E, CMPD2, HB1, HB2, HH1, IVF, LQT3, Nav1.5, SSS1, VF1, HBBD, ICCD, PFHB1
Protein Interaction Partner: CALM1, CAV3, ALB, Nedd4, WWP2, UBC, SNTG2, NEDD4L, DLG2, INADL, DLG4, RGS3, SNTA1, DLG1, RGS2, SCN5A, SNTB2, SNTB1, DLG3, CBL,
Protein Size: 2015 - 分子量
- 222 kDa
- 基因ID
- 6331
- NCBI登录号
- NM_000335, NP_000326
- UniProt
- Q8IZC9
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