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SCN5A 抗体 (N-Term)

SCN5A 适用: 人, 小鼠, 大鼠, 犬, Cow, 豚鼠, 马, 斑马鱼, 兔 WB, IHC 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN2776088
发货至: 中国
  • 抗原 See all SCN5A 抗体
    SCN5A (Sodium Channel, Voltage-Gated, Type V, alpha Subunit (SCN5A))
    抗原表位
    • 14
    • 7
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    N-Term
    适用
    • 33
    • 15
    • 15
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    人, 小鼠, 大鼠, 犬, Cow, 豚鼠, 马, 斑马鱼, 兔
    宿主
    • 32
    • 2
    • 1
    克隆类型
    • 35
    多克隆
    标记
    • 18
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This SCN5A antibody is un-conjugated
    应用范围
    • 25
    • 18
    • 7
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    序列
    SEADFADDEN STAGESESHH TSLLVPWPLR RTSAQGQPSP GTSAPGHALH
    预测反应
    Cow: 93%, Dog: 93%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 77%
    产品特性
    This is a rabbit polyclonal antibody against SCN5A. It was validated on Western Blot using a cell lysate as a positive control.
    纯化方法
    Affinity Purified
    免疫原
    The immunogen is a synthetic peptide directed towards the N terminal region of human SCN5A
    Top Product
    Discover our top product SCN5A Primary Antibody
  • 应用备注
    Optimal working dilutions should be determined experimentally by the investigator.
    说明

    Antigen size: 2015 AA

    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    Lot specific
    缓冲液
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freeze-thaw cycles.
    储存条件
    -20 °C
    储存方法
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Matsushita, Hirose, Sanbe, Kondo, Irie, Taira: "Nicorandil improves electrical remodelling, leading to the prevention of electrically induced ventricular tachyarrhythmia in a mouse model of desmin-related cardiomyopathy." in: Clinical and experimental pharmacology & physiology, Vol. 41, Issue 1, pp. 89-97, (2013) (PubMed).

  • 抗原
    SCN5A (Sodium Channel, Voltage-Gated, Type V, alpha Subunit (SCN5A))
    别名
    SCN5A (SCN5A 产品)
    别名
    Nav1.5 antibody, Nav1.5c antibody, SkM1 antibody, SkM2 antibody, mH1 antibody, CDCD2 antibody, CMD1E antibody, CMPD2 antibody, HB1 antibody, HB2 antibody, HBBD antibody, HH1 antibody, ICCD antibody, IVF antibody, LQT3 antibody, PFHB1 antibody, SSS1 antibody, VF1 antibody, SCAL antibody, sodium voltage-gated channel alpha subunit 5 antibody, sodium channel, voltage-gated, type V, alpha antibody, SCN5A antibody, Scn5a antibody
    背景
    SCN5A is an integral membrane protein and tetrodotoxin-resistant voltage-gated sodium channel subunit. The protein is found primarily in cardiac muscle and is responsible for the initial upstroke of the action potential in an electrocardiogram. The protein encoded by this gene is an integral membrane protein and tetrodotoxin-resistant voltage-gated sodium channel subunit. This protein is found primarily in cardiac muscle and is responsible for the initial upstroke of the action potential in an electrocardiogram. Defects in this gene are a cause of long QT syndrome type 3 (LQT3), an autosomal dominant cardiac disease. Alternative splicing results in several transcript variants encoding different isoforms.
    Alias Symbols: CDCD2, CMD1E, CMPD2, HB1, HB2, HBBD, HH1, ICCD, IVF, LQT3, Nav1.5, PFHB1, SSS1, VF1
    Protein Interaction Partner: CALM1, CAV3, ALB, Nedd4, WWP2, UBC, SNTG2, NEDD4L, DLG2, INADL, DLG4, RGS3, SNTA1, DLG1, RGS2, SCN5A, SNTB2, SNTB1, DLG3, CBL,
    Protein Size: 2015
    分子量
    227 kDa
    基因ID
    6331
    NCBI登录号
    NM_000335, NP_000326
    UniProt
    Q14524
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