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ErbB2/Her2 抗体 (AA 676-1255)

ErbB2/Her2 适用: 人 WB, IHC, IF, FACS 宿主: 小鼠 Monoclonal 9G2 unconjugated
产品编号 ABIN2717959
发货至: 中国
  • 抗原 See all ErbB2/Her2 抗体
    ErbB2/Her2 (Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2))
    抗原表位
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    AA 676-1255
    适用
    • 505
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    宿主
    • 404
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    小鼠
    克隆类型
    • 407
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    单克隆
    标记
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    This ErbB2/Her2 antibody is un-conjugated
    应用范围
    • 292
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    Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS)
    产品特性
    Homo sapiens v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) (ERBB2), transcript variant 1
    纯化方法
    Purified from mouse ascites fluids by affinity chromatography
    免疫原
    Human recombinant protein fragment corresponding to amino acids 676-1255 of human ERBB2(NP_004439) produced in HEK293T cell.
    克隆位点
    9G2
    亚型
    IgG2b
    Top Product
    Discover our top product ErbB2/Her2 Primary Antibody
  • 应用备注
    WB 1:2000, IHC 1:150, IF 1:100, FLOW 1:100,
    说明

    The concentration of the product may vary between diferrent lots.

    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    0.5-1.0 mg/mL
    缓冲液
    PBS (PH 7.3) containing 1 % BSA, 50 % glycerol and 0.02 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
  • 抗原
    ErbB2/Her2 (Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2))
    别名
    ERBB2 (ErbB2/Her2 产品)
    别名
    CD340 antibody, HER-2 antibody, HER-2/neu antibody, HER2 antibody, MLN 19 antibody, NEU antibody, NGL antibody, TKR1 antibody, Erbb-2 antibody, Neu antibody, c-erbB2 antibody, c-neu antibody, mKIAA3023 antibody, wu:fv70f10 antibody, zgc:63601 antibody, erb2 antibody, erb-b2 receptor tyrosine kinase 2 antibody, ERBB2 antibody, Erbb2 antibody, erbb2 antibody
    背景
    This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.
    分子量
    137.7 kDa
    基因ID
    2064
    NCBI登录号
    NM_004448
    HGNC
    2064
    途径
    RTK signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Skeletal Muscle Fiber Development
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