ErbB2/Her2 抗体 (C-Term)
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- 抗原 See all ErbB2/Her2 抗体
- ErbB2/Her2 (Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2))
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抗原表位
- C-Term
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This ErbB2/Her2 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC)
- 序列
- ARPAGATLER PKTLSPGKNG VVKDVFAFGG AVENPEYLTP QGGAAPQPHP PPAFSPAFDN LYYWDQDPPE RGAPPSTFKG TPTAENPEYL GLDVPV
- 交叉反应
- 人, 小鼠, 大鼠
- 产品特性
- Polyclonal Antibodies
- 纯化方法
- Affinity purification
- 免疫原
- A synthetic peptide corresponding to a sequence within amino acids 1160 to the C-terminus of human HER2 / ErbB2 (NP_004439.2).
- 亚型
- IgG
- Top Product
- Discover our top product ErbB2/Her2 Primary Antibody
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- 应用备注
- WB,1:500 - 1:2000,IHC,1:50 - 1:100
- 说明
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HIGH QUALITY
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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- 抗原
- ErbB2/Her2 (Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2))
- 别名
- ErbB2 (ErbB2/Her2 产品)
- 别名
- CD340 antibody, HER-2 antibody, HER-2/neu antibody, HER2 antibody, MLN 19 antibody, NEU antibody, NGL antibody, TKR1 antibody, Erbb-2 antibody, Neu antibody, c-erbB2 antibody, c-neu antibody, mKIAA3023 antibody, wu:fv70f10 antibody, zgc:63601 antibody, erb2 antibody, erb-b2 receptor tyrosine kinase 2 antibody, ERBB2 antibody, Erbb2 antibody, erbb2 antibody
- 背景
- This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.,ERBB2,CD340,HER-2,HER-2/neu,HER2,MLN 19,NEU,NGL,TKR1,erb-b2 receptor tyrosine kinase 2,HER2/ErbB2,ErbB2,MLN19,Cancer,Tumor immunology,Tumor-associated antigens,Tumor biomarkers,Signal Transduction,Kinase,Tyrosine kinases,ErbB-HER Signaling Pathway,Cell Biology & Developmental Biology,Growth factor,EGF,Immunology & Inflammation,CD markers,Cardiovascular,Angiogenesis,ErbB2
- 分子量
- 62 kDa/70 kDa/97 kDa/134 kDa/136 kDa/137 kDa
- 基因ID
- 2064
- UniProt
- P04626
- 途径
- RTK signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Skeletal Muscle Fiber Development
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