我们推荐在您的浏览器上开启Javascript，以获得最佳效果。

CD44 抗体

Name: CD44 抗体
SKU: ABIN2689263
Availability: OutOfStock

CD44 适用: 小鼠 FACS, IHC (fro), IHC (f) 宿主: 大鼠 Monoclonal IM7 unconjugated

(11 references)

产品编号 ABIN2689263

发货至: 中国

Datasheet as PDF

抗原 See all CD44 抗体

CD44
适用
293

152

81

30

25

24

16

11

9

9

8

6

5

4

4

3

2

1

1

1

1

1

1
小鼠
宿主
168

124

77

2

1
大鼠
Compatible Secondaries
克隆类型
254

116

2
单克隆
标记
165

42

30

26

18

8

8

6

6

5

5

5

5

5

4

4

3

3

3

3

3

2

2

2

2

1

1

1

1

1

1

1

1
This CD44 antibody is un-conjugated
应用范围
260

154

92

73

70

66

60

40

34

31

29

13

7

7

6

5

5

3

2

2

2

2

2

2

1

1

1

1

1

1
Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))

品牌

BD Pharmingen™

产品特性

The IM7 antibody reacts with an epitope on both alloantigens and all isoforms of the CD44 glycoprotein (Pgp-1, Ly-24). The standard form of CD44, lacking variable exons and referred to as CD44H or CD44s, is widely expressed on hematopoietic and non-hematopoietic cells. CD44 isoforms encoded by variable exons are expressed on epithelial cells, but only at low levels on most leukocytes. Mice with the Ly-24.1 alloantigen (e.g., BALB/c, CBA/J, DBA/1, DBA/2) have relatively large subsets of CD44H+ T lymphocytes, while Ly-24.2 strains (e.g., A, AKR, CBA/N, C3H/He, C57BL, C57BR, C57L, C58, NZB, SJL, SWR, 129) have few CD44H+ T cells. CD44 is a cell adhesion receptor, and its principal ligand, hyaluronate, is a common component of extracellular matrices. Differential glycosylation of CD44 influences its binding to hyaluronate. Additional ligands include the cell-surface form of CD74 and the cytokine osteopontin (Eta-1). Bone marrow- and thymus-derived progenitor cells capable of repopulating the thymus express CD44. In the periphery, the level of CD44 expression increases upon activation of B lymphocytes, CD4+ T cells, and CD8+ T cells, memory cells can be recognized by their CD44[hi] phenotype. The IM7 mAb inhibits established collagen-induced arthritis in DBA/1 mice. Moreover, it prevents CNS inflammation and clinical symptoms of experimental autoimmune encephalomyelitis. In contrast, the same antibody exacerbates experimental autoimmune thyroiditis in CBA/J mice. The IM7 mAb recognizes a different epitope from that recognized by mAb KM114 (Cat. No. 558739), and the antibody pair can be used in ELISA to detect soluble CD44. It has been observed that IM7 antibody cross-reacts with human, dog, cat, horse, cow, and pig leukocytes. Anti-human CD44, clone G44-26 (Cat. No. 555476), and IM7 antibody compete for binding to human peripheral blood lymphocytes. Immunohistochemical staining of CD44 positive cells.

BD Pharmingen™ Purified Rat Anti-Mouse CD44 - Purified - Clone IM7 - Isotype Rat IgG2b, κ - Reactivity Ms - 1 mL

纯化方法

The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

免疫原

Dexamethasone-induced cells of the SJL mouse spontaneous myeloid leukemia M1

克隆位点

IM7

亚型

IgG2b kappa

Top Product

Discover our top product CD44 Primary Antibody
anti-CD44 (CD44) antibody
CD44 适用: 人, 小鼠 FACS, WB, IHC, ELISA, ICC 宿主: 小鼠 Monoclonal 8E2F3 unconjugated

anti-CD44 (CD44) antibody
KO Validated CD44 适用: 人 WB, IHC (p), IF, IP, IHC (fro), ICC, LCI 宿主: 兔 Polyclonal unconjugated

anti-CD44 (CD44) (AA 21-220) antibody
CD44 适用: 人 FACS, WB, IHC, ELISA, IF 宿主: 小鼠 Monoclonal 6G2D2 unconjugated

anti-CD44 (CD44) antibody
CD44 适用: 人, 小鼠, 大鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-CD44 (CD44) antibody
CD44 适用: 人 FACS, WB, IHC, ELISA, IHC (p), IP, Inhibition 宿主: 小鼠 Monoclonal MEM-85 unconjugated

anti-CD44 (CD44) antibody
CD44 适用: 人, 犬, Pig FACS, WB, IHC (p), IP 宿主: 小鼠 Monoclonal MEM-263 unconjugated

anti-CD44 (CD44) (AA 346-385) antibody
CD44 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-CD44 (CD44) (AA 148-247) antibody
CD44 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-CD44 (CD44) antibody
CD44 适用: 人 WB, IHC 宿主: 兔 Monoclonal unconjugated

anti-CD44 (CD44) (AA 36-194) antibody
CD44 适用: 人 FACS, WB, IHC, ELISA, ICC, Neut 宿主: 小鼠 Monoclonal 7F4F12 unconjugated

应用备注

Optimal working dilution should be determined by the investigator.

限制

仅限研究用
状态

Liquid

浓度

62.5 μg/mL

缓冲液

Aqueous buffered solution containing BSA, goat serum, and ≤0.09 % sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C

储存方法

Store undiluted at 4°C.
Naor, Sionov, Ish-Shalom: "CD44: structure, function, and association with the malignant process." in: Advances in cancer research, Vol. 71, Issue 4, pp. 241-319, (1997) (PubMed).

Weber, Ashkar, Glimcher, Cantor: "Receptor-ligand interaction between CD44 and osteopontin (Eta-1)." in: Science (New York, N.Y.), Vol. 271, Issue 5248, pp. 509-12, (1996) (PubMed).

Katoh, Zheng, Oritani, Shimozato, Kincade: "Glycosylation of CD44 negatively regulates its recognition of hyaluronan." in: The Journal of experimental medicine, Vol. 182, Issue 2, pp. 419-29, (1995) (PubMed).

Bendelac: "Mouse NK1+ T cells." in: Current opinion in immunology, Vol. 7, Issue 3, pp. 367-74, (1995) (PubMed).

Katoh, McCarthy, Kincade: "Characterization of soluble CD44 in the circulation of mice. Levels are affected by immune activity and tumor growth." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 153, Issue 8, pp. 3440-9, (1994) (PubMed).

Lesley, Hyman, Kincade: "CD44 and its interaction with extracellular matrix." in: Advances in immunology, Vol. 54, Issue 4, pp. 271-335, (1993) (PubMed).

Vremec, Zorbas, Scollay, Saunders, Ardavin, Wu, Shortman: "The surface phenotype of dendritic cells purified from mouse thymus and spleen: investigation of the CD8 expression by a subpopulation of dendritic cells." in: The Journal of experimental medicine, Vol. 176, Issue 1, pp. 47-58, (1992) (PubMed).

Lynch, Ceredig: "Mouse strain variation in Ly-24 (Pgp-1) expression by peripheral T cells and thymocytes: implications for T cell differentiation." in: European journal of immunology, Vol. 19, Issue 2, pp. 223-9, (1989) (PubMed).

Hyman, Lesley, Schulte, Trotter: "Progenitor cells in the thymus: most thymus-homing progenitor cells in the adult mouse thymus bear Pgp-1 glycoprotein but not interleukin-2 receptor on their cell surface." in: Cellular immunology, Vol. 101, Issue 2, pp. 320-7, (1986) (PubMed).

Lesley, Trowbridge: "Genetic characterization of a polymorphic murine cell-surface glycoprotein." in: Immunogenetics, Vol. 15, Issue 3, pp. 313-20, (1982) (PubMed).

Trowbridge, Lesley, Schulte, Hyman, Trotter: "Biochemical characterization and cellular distribution of a polymorphic, murine cell-surface glycoprotein expressed on lymphoid tissues." in: Immunogenetics, Vol. 15, Issue 3, pp. 299-312, (1982) (PubMed).
抗原

CD44

别名

CD44 (CD44 产品)

别名

CDW44 antibody, CSPG8 antibody, ECMR-III antibody, HCELL antibody, HUTCH-I antibody, IN antibody, LHR antibody, MC56 antibody, MDU2 antibody, MDU3 antibody, MIC4 antibody, Pgp1 antibody, AU023126 antibody, AW121933 antibody, AW146109 antibody, HERMES antibody, Ly-24 antibody, Pgp-1 antibody, CD44A antibody, METAA antibody, RHAMM antibody, XCD44 antibody, cd44 antibody, cdw44 antibody, cspg8 antibody, ecmr-iii antibody, hcell antibody, lhr antibody, mc56 antibody, mdu2 antibody, mdu3 antibody, mic4 antibody, mutch-i antibody, pgp1 antibody, CD44 molecule (Indian blood group) antibody, syndecan 4 antibody, CD44 antigen antibody, CD44 molecule (Indian blood group) S homeolog antibody, CD44 antibody, SDC4 antibody, Cd44 antibody, cd44.S antibody

背景

Synonyms: Pgp-1, H-CAM, Ly-24

途径

Glycosaminoglycan Metabolic Process, Autophagy, Negative Regulation of intrinsic apoptotic Signaling