CD130, also known as gp130 (glycoprotein 130), IL6ST (IL-6-receptor-associated signal transducer), or common β chain, is a member of the hematopoietic cytokine receptor family. CD130 is a common subunit associated with the receptors for several cytokines, such as IL-6, IL-11, Oncostatin M (OSM), CNTF (ciliary neurotrophic factor), CT-1, Neuropoietin (NP), and IL-27. CD130 participates in the JAK-STAT signaling pathway and is expressed on T cells, activated B cells, monocytes, plasma cells, and endothelial or epithelial cells.