IRF7 抗体 (Alexa Fluor 488)
Quick Overview for IRF7 抗体 (Alexa Fluor 488) (ABIN2657088)
抗原
See all IRF7 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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纯化方法
- The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 488 under optimal conditions.
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亚型
- IgG2b kappa
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anti-Interferon Regulatory Factor 7 (IRF7) (pSer471), (pSer472) antibody
IRF7 适用: 人, 小鼠, 大鼠 WB, ELISA, FACS, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Interferon Regulatory Factor 7 (IRF7) (AA 401-503) antibodyIRF7 适用: 人, 小鼠, 大鼠, Pig WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Interferon Regulatory Factor 7 (IRF7) (AA 131-289) antibodyIRF7 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Interferon Regulatory Factor 7 (IRF7) (AA 1-150), (N-Term) antibodyIRF7 适用: 人 WB, IHC (p), EIA 宿主: 小鼠 Monoclonal 3D9 unconjugated
anti-Interferon Regulatory Factor 7 (IRF7) antibodyIRF7 适用: 人 WB, IF (cc) 宿主: 兔 Monoclonal 2A1 unconjugated
anti-Interferon Regulatory Factor 7 (IRF7) (AA 257-516) antibodyIRF7 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Interferon Regulatory Factor 7 (IRF7) (C-Term) antibodyIRF7 适用: 人, 小鼠, 大鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
anti-Interferon Regulatory Factor 7 (IRF7) (AA 35-84) antibodyIRF7 适用: 人, 小鼠, 大鼠, 马 WB 宿主: 兔 Polyclonal unconjugated
anti-Interferon Regulatory Factor 7 (IRF7) (AA 1-150) antibodyIRF7 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3D9 unconjugated
anti-Interferon Regulatory Factor 7 (IRF7) (N-Term) antibodyIRF7 适用: 人, 小鼠, 大鼠, Pig, 斑马鱼, 马, Cow, 兔 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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缓冲液
- Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide and 0.2 % (w/v) BSA .
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Protect from prolonged exposure to light. Do not freeze.
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储存条件
- 4 °C
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储存方法
- The antibody solution should be stored undiluted between 2°C and 8°C
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- IRF7 (Interferon Regulatory Factor 7 (IRF7))
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别名
- IRF7
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背景
- IRF-7 is a member of the interferon regulatory transcription factor family that plays key regulatory roles in innate immunity. Upon virus infection, IRF-7 forms a complex with MyD88 and TRAF6 when stimulated by toll-like receptors TLR7, TLR8, and TLR9, which in turn results in nuclear translocation and induction of interferon gene expression. IRF-7 gene expression is upregulated by the stimulation of interferon through the Jak-STAT signaling pathway, which forms a positive feedback loop. The protein level of IRF-7 after activation is then downregulated by the ubiquitin-proteasome system to avoid excessive production of interferons that may cause damage to the host. Virus induced type I interferon expression was completely abrogated in IRF-7 knockout mice, suggesting that IRF-7 is critical for interferon mediated host defense during virus infection.
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途径
- TLR signaling, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades, Autophagy
抗原
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