Ret Proto-Oncogene 抗体 (AA 896-1063)
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- 抗原 See all Ret Proto-Oncogene (RET) 抗体
- Ret Proto-Oncogene (RET)
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抗原表位
- AA 896-1063
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This Ret Proto-Oncogene antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA
- 免疫原
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Purified truncated recombinant RET (aa896-1063)-GST fusion protein is expressed in E. Coli strain BL21 (DE3).
- 克隆位点
- 6E4C4
- 亚型
- IgG1
- Top Product
- Discover our top product RET Primary Antibody
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- 应用备注
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Western Blot:1:500 - 1:2,000
IHC(P):1:500 - 1:2,000
ELISA:Propose dilution 1:10,000.
Determining optimal working dilutions by titration test.
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- Ascitic fluid containing 0.03 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
- 储存条件
- -20 °C
- 储存方法
- RET monoclonal antibody can be stored at -20 °C, stable for one year.
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- 抗原
- Ret Proto-Oncogene (RET)
- 别名
- RET (RET 产品)
- 别名
- c-ret antibody, cret antibody, etID315074.13 antibody, ret1 antibody, wu:fd13h01 antibody, X-ret antibody, ret-A antibody, xret antibody, RET antibody, MTC1 antibody, CDHF12 antibody, CDHR16 antibody, HSCR1 antibody, MEN2A antibody, MEN2B antibody, PTC antibody, RET-ELE1 antibody, RET51 antibody, RET9 antibody, c-Ret antibody, ret proto-oncogene receptor tyrosine kinase antibody, ret proto-oncogene S homeolog antibody, ret proto-oncogene antibody, ret antibody, ret.S antibody, RET antibody, Ret antibody
- 背景
- RET (ret proto-oncogene) is a member of the cadherin superfamily and a receptor tyrosine kinase, which are cell-surface molecules that transduce signals for cell growth and differentiation. It can undergo oncogenic activation in vivo and in vitro by cytogenetic rearrangement. Ligands that bind the Ret receptor include the glial cell line-derived neurotropic factor (GDNF) and its congeners neurturin, persephin and artemin. Alterations in the corresponding Ret gene are associated with diseases including papillary thyroid carcinoma, multiple endocrine neoplasia (type 2A and 2B), familial medullary thyroid carcinoma and a congenital developmental disorder known as Hirschsprung? disease. The Tyr905 residue located in the Ret kinase domain plays a crucial role in Ret catalytic and biological activity. Substitution of Phe for Tyr905 dramatically inhibits Ret autophosphorylation activity.
- 基因ID
- 5979
- UniProt
- P07949
- 途径
- RTK signaling, Dopaminergic Neurogenesis, Regulation of Cell Size, Tube Formation
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