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- 抗原 See all UBA3 抗体
- UBA3 (Ubiquitin-Like Modifier Activating Enzyme 3 (UBA3))
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适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This UBA3 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA
- 纯化方法
- Antibody is purified by peptide affinity chromatography method.
- 免疫原
- Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human UBA3.
- Top Product
- Discover our top product UBA3 Primary Antibody
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anti-Ubiquitin-Like Modifier Activating Enzyme 3 (UBA3) (AA 415-445), (C-Term) antibody
UBA3 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB2803 unconjugated
anti-Ubiquitin-Like Modifier Activating Enzyme 3 (UBA3) (Internal Region) antibodyUBA3 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin-Like Modifier Activating Enzyme 3 (UBA3) antibodyUBA3 适用: 人 WB 宿主: 兔 Monoclonal unconjugated
anti-Ubiquitin-Like Modifier Activating Enzyme 3 (UBA3) (AA 409-448), (C-Term) antibodyUBA3 适用: 人, 小鼠, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin-Like Modifier Activating Enzyme 3 (UBA3) (N-Term) antibodyUBA3 适用: 人, 小鼠, 大鼠, Cow, 犬, 斑马鱼, 马, Pig, 兔 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin-Like Modifier Activating Enzyme 3 (UBA3) antibodyUBA3 适用: 人, 小鼠, 大鼠 IHC 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin-Like Modifier Activating Enzyme 3 (UBA3) (AA 234-463), (Catalytic Subunit) antibodyUBA3 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin-Like Modifier Activating Enzyme 3 (UBA3) (AA 35-84) antibodyUBA3 适用: 人, 小鼠, 大鼠, Cow, 犬, 斑马鱼, 马, Pig, 兔, 小鸡, Bat, Hamster, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin-Like Modifier Activating Enzyme 3 (UBA3) (AA 1-229) antibodyUBA3 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin-Like Modifier Activating Enzyme 3 (UBA3) (C-Term) antibodyUBA3 适用: 人, 小鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- UBA3 antibody can be used for detection of UBA3 by ELISA at 1:1562500. UBA3 antibody can be used for detection of UBA3 by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.
- 浓度
- 1 mg/mL
- 缓冲液
- Antibody is lyophilized in PBS buffer with 2 % sucrose.
- 注意事项
- As with any antibody avoid repeat freeze-thaw cycles.
- 储存条件
- 4 °C/-20 °C
- 储存方法
- For short periods of storage (days) store at 4 °C. For longer periods of storage, store UBA3 antibody at -20 °C.
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- 抗原
- UBA3 (Ubiquitin-Like Modifier Activating Enzyme 3 (UBA3))
- 别名
- UBA3 (UBA3 产品)
- 别名
- UBE1C antibody, hUBA3 antibody, Ube1c antibody, ube1c antibody, wu:fb75e04 antibody, wu:fc37b11 antibody, zgc:55528 antibody, A830034N06Rik antibody, AI256736 antibody, AI848246 antibody, AW546539 antibody, ubiquitin like modifier activating enzyme 3 antibody, ubiquitin-like modifier activating enzyme 3 antibody, ubiquitin like modifier activating enzyme 3 S homeolog antibody, UBA3 antibody, Uba3 antibody, uba3 antibody, uba3.S antibody
- 背景
- UBA3 is a catalytic subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. UBA3 down-regulates steroid receptor activity. UBA3 is necessary for cell cycle progression.The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme associates with AppBp1, an amyloid beta precursor protein binding protein, to form a heterodimer, and then the enzyme complex activates NEDD8, a ubiquitin-like protein, which regulates cell division, signaling and embryogenesis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
- 分子量
- 52 kDa
- 基因ID
- 9039
- NCBI登录号
- NP_003959
- UniProt
- Q8TBC4
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