UBA3 抗体 (N-Term)
Our Local Distributor
北京 101111
Quick Overview for UBA3 抗体 (N-Term) (ABIN2784205)
抗原
See all UBA3 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- N-Term
-
原理
- UBA3 Antibody - N-terminal region
-
序列
- EGRWNHVKKF LERSGPFTHP DFEPSTESLQ FLLDTCKVLV IGAGGLGCEL
-
预测反应
- Cow: 100%, Dog: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 86%
-
产品特性
- This is a rabbit polyclonal antibody against UBA3. It was validated on Western Blot using a cell lysate as a positive control.
-
纯化方法
- Affinity Purified
-
免疫原
- The immunogen is a synthetic peptide directed towards the N terminal region of human UBA3
-
-
anti-Ubiquitin-Like Modifier Activating Enzyme 3 (UBA3) (C-Term) antibody
UBA3 适用: 人, 小鼠, 大鼠 WB, IHC, FACS, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin-Like Modifier Activating Enzyme 3 (UBA3) (AA 415-445), (C-Term) antibodyUBA3 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB2803 unconjugated
anti-Ubiquitin-Like Modifier Activating Enzyme 3 (UBA3) antibodyUBA3 适用: 人 WB 宿主: 兔 Monoclonal unconjugated
anti-Ubiquitin-Like Modifier Activating Enzyme 3 (UBA3) (AA 35-84) antibodyUBA3 适用: 人, 小鼠, 大鼠, 斑马鱼, Cow, 犬, 马, Pig, 兔, 小鸡, Bat, Hamster, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin-Like Modifier Activating Enzyme 3 (UBA3) (N-Term) antibodyUBA3 适用: 人, 小鼠, 大鼠, 斑马鱼, Cow, 犬, 小鸡, 非洲爪蟾 WB 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin-Like Modifier Activating Enzyme 3 (UBA3) (Internal Region) antibodyUBA3 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin-Like Modifier Activating Enzyme 3 (UBA3) (AA 234-463), (Catalytic Subunit) antibodyUBA3 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin-Like Modifier Activating Enzyme 3 (UBA3) (AA 1-229) antibodyUBA3 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
- Optimal working dilution should be determined by the investigator.
-
说明
-
We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP50493-100UG
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
浓度
- 0.5 mg/mL
-
缓冲液
- Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
注意事项
- prevent freeze-thaw cycles
-
储存条件
- 4 °C,-20 °C
-
储存方法
- For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.
-
-
- UBA3 (Ubiquitin-Like Modifier Activating Enzyme 3 (UBA3))
-
别名
- UBA3
-
背景
-
Background Information: UBA3 is a catalytic subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. UBA3 down-regulates steroid receptor activity. UBA3 is necessary for cell cycle progression.The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme associates with AppBp1, an amyloid beta precursor protein binding protein, to form a heterodimer, and then the enzyme complex activates NEDD8, a ubiquitin-like protein, which regulates cell division, signaling and embryogenesis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Gene Name: Ubiquitin-like modifier activating enzyme 3
Alternative Symbols: NAE2, UBE1C, hUBA3
Protein Name: NEDD8-activating enzyme E1 catalytic subunit
-
分子量
- 52kDa
-
基因ID
- 9039
-
NCBI登录号
- NP_003959
-
UniProt
- Q8TBC4
抗原
-
