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Caspase 12 抗体

CASP12 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN2431120
发货至: 中国
  • 抗原 See all Caspase 12 (CASP12) 抗体
    Caspase 12 (CASP12) (Caspase 12 (Gene/pseudogene) (CASP12))
    适用
    • 62
    • 54
    • 33
    人, 小鼠
    宿主
    • 89
    • 3
    • 1
    克隆类型
    • 90
    • 3
    多克隆
    标记
    • 40
    • 8
    • 6
    • 6
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    This Caspase 12 antibody is un-conjugated
    应用范围
    • 79
    • 40
    • 29
    • 28
    • 26
    • 26
    • 21
    • 19
    • 10
    • 6
    • 5
    • 5
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
    纯化方法
    Affinity purification
    免疫原
    Synthetic peptide of human CASP12
    亚型
    IgG
    Top Product
    Discover our top product CASP12 Primary Antibody
  • 应用备注
    WB 1:500-1:2000, IHC 1:50-1:200
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    0.4 mg/mL
    缓冲液
    PBS with 0.05 % sodium azide and 50 % glycerol, PH7.4
    储存液
    Sodium azide
    注意事项
    Avoid freeze / thaw cycles.
    储存条件
    -20 °C
    储存方法
    Store at -20°C. Avoid freeze / thaw cycles.
  • 抗原
    Caspase 12 (CASP12) (Caspase 12 (Gene/pseudogene) (CASP12))
    别名
    CASP12 (CASP12 产品)
    别名
    Caspase-12 antibody, CASP-12 antibody, CASP12P1 antibody, caspase 12 antibody, caspase 12 (gene/pseudogene) antibody, Casp12 antibody, CASP12 antibody
    背景
    Caspases are cysteine proteases that cleave C-terminal aspartic acid residues on their substrate molecules. This gene is most highly related to members of the ICE subfamily of caspases that process inflammatory cytokines. In rodents, the homolog of this gene mediates apoptosis in response to endoplasmic reticulum stress. However, in humans this gene contains a polymorphism for the presence or absence of a premature stop codon. The majority of human individuals have the premature stop codon and produce a truncated non-functional protein. The read-through codon occurs primarily in individuals of African descent and carriers have endotoxin hypo-responsiveness and an increased susceptibility to severe sepsis. Several alternatively spliced transcript variants have been noted for this gene.
    分子量
    Calculated MW: 55 kDa
    NCBI登录号
    NP_001177945
    途径
    Apoptosis, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Unfolded Protein Response
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