CISH 1,CISH1,Cytokine inducible SH2 protein 1,JAB,JAK binding protein,JAK-binding protein,Janus kinase binding protein,SOCS 1,SOCS-1,Socs1,SOCS1,SSI 1,SSI-1,SSI1,STAT induced STAT inhibitor 1,STAT-induced STAT inhibitor 1,Suppressor of cytokine signaling 1,Supressor of cytokine signalling 1,TEC interacting protein 3,Tec-interacting protein 3,TIP 3,TIP-3,TIP3,This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival.