COL2 抗体 (CII-J1 epitope)
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- 抗原 See all COL2 抗体
- COL2 (Collagen, Type II (COL2))
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抗原表位
- CII-J1 epitope
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适用
- 小鼠
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This COL2 antibody is un-conjugated
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应用范围
- Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Functional Studies (Func), Detection (D), Immunoassay (IA)
- 过滤
- 0.2 μm filtered
- 克隆位点
- M2139
- Top Product
- Discover our top product COL2 Primary Antibody
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anti-Collagen, Type II (COL2) (AA 1201-1300) antibody
COL2 适用: 人, 小鼠, 大鼠, 兔, 豚鼠 WB, ELISA, IHC (p), IHC (fro), FACS, IF (cc), IF (p) 宿主: 兔 Polyclonal unconjugated
anti-Collagen, Type II (COL2) antibodyCOL2 适用: 人, 小鼠, 大鼠, Cow, 哺乳动物, 绵羊 WB, ELISA, IHC, IP 宿主: 兔 Polyclonal unconjugated
anti-Collagen, Type II (COL2) antibodyCOL2 适用: 人 ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Collagen, Type II (COL2) (N-Term) antibodyCOL2 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF/ICC 宿主: 兔 Polyclonal unconjugated
anti-Collagen, Type II (COL2) (AA 1401-1487) antibodyCOL2 适用: 人, 大鼠, 兔 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Collagen, Type II (COL2) (AA 101-150) antibodyCOL2 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Collagen, Type II (COL2) antibodyCOL2 适用: 人, 小鼠, 大鼠 IHC (p) 宿主: 小鼠 Monoclonal 1H1 unconjugated
anti-Collagen, Type II (COL2) antibody (Biotin)COL2 适用: 人 ELISA 宿主: 山羊 Polyclonal Biotin
anti-Collagen, Type II (COL2) antibody (FITC)COL2 适用: 人, Cow, 哺乳动物 WB, ELISA, IHC, IP 宿主: 兔 Polyclonal FITC
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- 应用备注
- For immunohistology dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:10.
- 限制
- 仅限研究用
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- 缓冲液
- PBS and 0.1 % bovine serum albumin
- 储存条件
- 4 °C
- 储存方法
- Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.
- 有效期
- 12 months
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- 抗原
- COL2 (Collagen, Type II (COL2))
- 别名
- Collagen Type II (COL2 产品)
- 别名
- PT antibody, RPRGL2 antibody, THPH1 antibody, Cf-2 antibody, Cf2 antibody, FII antibody, thrombin antibody, prothrombin antibody, CAP18 antibody, Cnlp antibody, Cramp antibody, FALL39 antibody, MCLP antibody, coagulation factor II, thrombin antibody, coagulation factor II antibody, cathelicidin antimicrobial peptide antibody, Cuticle collagen 2 antibody, collagen type II alpha 1 chain antibody, F2 antibody, Camp antibody, col-2 antibody, COL2A1 antibody
- 背景
- The monoclonal antibody M2139 reacts with the J1 epitope (triple helical position 551-564) of collagen type II. Collagen is a structural protein in bone, cartillage and connective tissue. Collagen type II (CII) is the major collagen of the nucleus pulposa (a component of spine), cartilage and vitreous (a component of the eye). The most commonly used animal model for rheumatoid arthritis (RA) is the collagen-induced arthritis (CIA). Transfer of collagen type II specific monoclonal antibodies induces an acute form of arthritis (collagen type II antibody induced arthritis, CAIA). The monocolonal antibody M2139 has been shown to induce CAIA in naive mice after injection of lipopolysacharide (LPS). However, in combination with the monoclonal antibody CIIC1, binding to the C1 epitope of CII, the pair of monoclonal antibodies induce arthritis in different strains of mice without any other stimulants. The presence of secondary stimulus, LPS, increases the disease incidence and severity. The monoclonal antibody M2139 is cross reactive with rat, bovine, chicken and human CII.
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