USP5 抗体
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- 抗原 See all USP5 抗体
- USP5 (Ubiquitin Specific Peptidase 5 (USP5))
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适用
- 人, 小鼠, 大鼠
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This USP5 antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 纯化方法
- This antibody is purified through a protein G column, followed by dialysis against PBS.
- 免疫原
- This USP5 antibody is generated from a mouse immunized with a recombination protein from the human region of human USP5.
- 克隆位点
- 1340CT704-170-140
- 亚型
- IgG1 kappa
- Top Product
- Discover our top product USP5 Primary Antibody
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- 应用备注
- WB: 1:2000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 有效期
- 6 months
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cDNA cloning of a human 100 kDa de-ubiquitinating enzyme: the 100 kDa human de-ubiquitinase belongs to the ubiquitin C-terminal hydrolase family 2 (UCH2)." in: FEBS letters, Vol. 376, Issue 3, pp. 233-7, (1996) (PubMed).
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cDNA cloning of a human 100 kDa de-ubiquitinating enzyme: the 100 kDa human de-ubiquitinase belongs to the ubiquitin C-terminal hydrolase family 2 (UCH2)." in: FEBS letters, Vol. 376, Issue 3, pp. 233-7, (1996) (PubMed).
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- 抗原
- USP5 (Ubiquitin Specific Peptidase 5 (USP5))
- 别名
- USP5 (USP5 产品)
- 别名
- ISOT antibody, AA407472 antibody, ISOT-1 antibody, Ucht antibody, ubiquitin specific peptidase 5 antibody, ubiquitin carboxyl-terminal hydrolase 5 antibody, ubiquitin carboxyl-terminal hydrolase 5, putative antibody, ubiquitin specific protease 5 antibody, ubiquitin specific peptidase 5 (isopeptidase T) antibody, USP5 antibody, CNH02890 antibody, EHI_049940 antibody, CC1G_12961 antibody, MCYG_01862 antibody, CGB_L3600C antibody, PY00546 antibody, Usp5 antibody
- 背景
- Cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers. Involved in unanchored 'Lys-48'-linked polyubiquitin disassembly. Binds linear and 'Lys- 63'-linked polyubiquitin with a lower affinity. Knock-down of USP5 causes the accumulation of p53/TP53 and an increase in p53/TP53 transcriptional activity because the unanchored polyubiquitin that accumulates is able to compete with ubiquitinated p53/TP53 but not with MDM2 for proteasomal recognition.
- 分子量
- 95786
- 基因ID
- 8078
- UniProt
- P45974
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