Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP)
特异性
The antibody reacts with the 165 kDa desmoglein 2 protein. Furthermore it does NOT cross-react with desmoglein 1 or desmolglein 3. Clone 6D8 does NOT inhibit the biological activity of desmoglein 2. Species Reactivity: Human. NOT suitable for rat tissues. Others not tested.
Immunofluorescence: Use at a 1:10 dilution. Immunoprecipitation Western blotting: Use at a 1:10 dilution. The optimal dilution for a specific application should be determined by the researcher.
限制
仅限研究用
状态
Liquid
缓冲液
1 mL at 100 µg/mL of 0.2 µm filtered antibody solution in PBS, containing 0.02% sodium azide and 0.1% protein stabilizer.
储存液
Sodium azide
注意事项
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Desmoglein 2 is a member of the desmosomal cadherin family that comprise the desmogleins and desmocollins. Desmosomes are cell-cell junctions in most epithelial cells and serve to link the intermediate filament cytoskeletons of adjacent cells. Within the desmosome the extracellular desmocollins, whereas the intracellular domain is essential for binding to the desmosomal plaque protein, plakoglobin. Desmoglein 2 is synthesized in the basal layers, depending on the certain types of epidermis.