PAG1 抗体 (AA 97-432)
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- 抗原 See all PAG1 抗体
- PAG1 (phosphoprotein Associated with Glycosphingolipid Microdomains 1 (PAG1))
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抗原表位
- AA 97-432
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This PAG1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunoprecipitation (IP)
- 特异性
- Csk binding protein, also known as PAG (phosphoprotein associated with GEMs), is a ubiquitously expressed 46 kD transmembrane adaptor protein present in membrane rafts (glycosphingolipid-enriched microdomains), which however migrates on SDS PAGE gels anomalously as an 80 kD molecule. Following tyrosine phosphorylation by Src family kinases, PAG binds and thereby activates the protein tyrosine kinase Csk, the major negative regulator of the Src family kinases. Signaling via the B-cell receptor in B cells or high affinity IgE receptor (FcepsilonRI) in mast cells leads to PAG increased tyrosine phosphorylation and Csk binding, while T cell receptor signaling causes PAG dephosphorylation, loss of Csk binding and increased activation of the protein tyrosine kinase Lck.
- 纯化方法
- Purified
- 免疫原
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Recombinant intracellular fragment (aa 97-432) of human Cbp/PAG.
Type of Immunogen: Recombinant protein - Top Product
- Discover our top product PAG1 Primary Antibody
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 说明
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Target Species of Antibody: Human
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- Lot specific
- 缓冲液
- PBS, pH 7.4, 15 mM sodium azide
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freezing and thawing.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Short term: 4°C. Long term: Store at -20°C. Avoid freeze-thaw cycles.
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- 抗原
- PAG1 (phosphoprotein Associated with Glycosphingolipid Microdomains 1 (PAG1))
- 别名
- PAG1 / PAG (PAG1 产品)
- 别名
- Cbp antibody, F730007C19Rik antibody, Pag antibody, CBP antibody, PAG antibody, MGC80192 antibody, phosphoprotein associated with glycosphingolipid microdomains 1 antibody, phosphoprotein membrane anchor with glycosphingolipid microdomains 1 antibody, phosphoprotein membrane anchor with glycosphingolipid microdomains 1 L homeolog antibody, Pag1 antibody, PAG1 antibody, pag1.L antibody, pag1 antibody
- 背景
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Name/Gene ID: PAG1
Synonyms: PAG1, Csk-binding protein, CBP, PAG - 基因ID
- 55824
- UniProt
- Q9NWQ8
- 途径
- p53 Pathway, TCR Signaling, EGFR Signaling Pathway, CXCR4-mediated Signaling Events
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