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PAG1 抗体 (AA 97-432)

PAG1 适用: 人, 小鼠 WB, IP, IHC (p) 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN94497
发货至: 中国
  • 抗原 See all PAG1 抗体
    PAG1 (phosphoprotein Associated with Glycosphingolipid Microdomains 1 (PAG1))
    抗原表位
    • 16
    • 9
    • 4
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 97-432
    适用
    • 28
    • 26
    • 23
    • 12
    • 1
    • 1
    • 1
    • 1
    • 1
    人, 小鼠
    宿主
    • 42
    • 4
    克隆类型
    • 42
    • 4
    多克隆
    标记
    • 18
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This PAG1 antibody is un-conjugated
    应用范围
    • 33
    • 16
    • 13
    • 13
    • 12
    • 7
    • 6
    • 6
    • 4
    • 3
    • 2
    • 1
    Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    特异性
    The polyclonal antibody recognizes intracellular part of Csk-binding protein (Cbp / PAG), a 46 kDa ubiquitously expressed transmembrane adaptor protein present in membrane rafts (glycosphingolipid-enriched microdomains), which however migrates on SDS PAGE gels anomalously as an 80 kDa molecule.
    交叉反应 (详细)
    Mouse, Human
    纯化方法
    Purified by protein-A affinity chromatography.
    纯度
    > 95 % (by SDS-PAGE)
    免疫原
    Recombinant intracellular fragment (aa 97-432) of human Cbp (PAG).
  • 应用备注
    Immunohistochemistry (paraffin sections): Positive tissue: tonsil, colon germinal center.
    Western blotting: Recommended dilution: 1-2 μg/mL.
    限制
    仅限研究用
  • 浓度
    1 mg/mL
    缓冲液
    Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Do not freeze.
    储存条件
    4 °C
    储存方法
    Store at 2-8°C. Do not freeze.
  • 抗原
    PAG1 (phosphoprotein Associated with Glycosphingolipid Microdomains 1 (PAG1))
    别名
    PAG / Cbp (PAG1 产品)
    别名
    Cbp antibody, F730007C19Rik antibody, Pag antibody, CBP antibody, PAG antibody, MGC80192 antibody, phosphoprotein associated with glycosphingolipid microdomains 1 antibody, phosphoprotein membrane anchor with glycosphingolipid microdomains 1 antibody, phosphoprotein membrane anchor with glycosphingolipid microdomains 1 L homeolog antibody, Pag1 antibody, PAG1 antibody, pag1.L antibody, pag1 antibody
    背景
    Phosphoprotein membrane anchor with glycosphingoli,PAG (phosphoprotein associated with GEMs), also known as Cbp (Csk-binding protein), is a ubiquitously expressed 46 kDa transmembrane adaptor protein present in membrane rafts (glycosphingolipid-enriched microdomains), which however migrates on SDS PAGE gels anomalously as an 80 kDa molecule. Following tyrosine phosphorylation by Src family kinases, PAG binds and thereby activates the protein tyrosine kinase Csk, the major negative regulator of the Src family kinases. Signaling via the B-cell receptor in B cells or high affinity IgE receptor (FcepsilonRI) in mast cells leads to PAG increased tyrosine phosphorylation and Csk binding, while T cell receptor signaling causes PAG dephosphorylation, loss of Csk binding and increased activation of the protein tyrosine kinase Lck.,CBP, PAG
    基因ID
    94212
    UniProt
    Q3U1F9
    途径
    p53 Pathway, TCR Signaling, EGFR Signaling Pathway, CXCR4-mediated Signaling Events
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