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PINK1 抗体 (AA 258-274)
PINK1
适用: 人
WB
宿主: 兔
Polyclonal
unconjugated
PINK1抗体详情
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抗原
See all PINK1 抗体
PINK1
(PTEN Induced Putative Kinase 1 (PINK1))
抗原表位
All epitopes for PINK1 抗体
AA 258-274
适用
All reactivities for PINK1 抗体
人
宿主
All hosts for PINK1 抗体
兔
克隆类型
All clonalities for PINK1 抗体
多克隆
标记
All conjugates for PINK1 抗体
This PINK1 antibody is un-conjugated
应用范围
All applications for PINK1 抗体
Western Blotting (WB)
特异性
Reacts with human PINK1.
纯化方法
Purified
免疫原
Synthetic peptide corresponding to amino acids 258-274 (YRKSKRGPKQLAPHPNI) of human PINK1 conjugated to KLH.
亚型
IgG
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Alternatives
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使用细节
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应用备注
Working dilution: Optimal dilution should be determined by the end user. The following are guidelines only : WB 1:500 dilution Positive control: Transfected cell lines
限制
仅限研究用
贮存及处理
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缓冲液
PBS, pH 7.4,
注意事项
Dilute in PBS or medium which is identical to that used in the assay system.
储存条件
4 °C/-20 °C
储存方法
Short term storage at+4°C. For extended periods store in aliquots at -20°C. Antibodies are guaranteed for 6 months from date of receipt.
有效期
6 months
PINK1目标详情
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抗原
PINK1
(PTEN Induced Putative Kinase 1 (PINK1))
别名
PINK1 (PINK1 产品 )
别名
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背景
PTEN induced putative kinase 1 (Pink1) was first discovered when researching the PTEN signaling pathway, thus Pink1 is also involved in many human cancers.It is found in the mitochondria and its homozygous C-terminus mutation has been implicated in the early development of Parkinson's disease. It protects against mitochondrial dysfunction during cellular stress, potentially by phosphorylating mitochondrial proteins. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy). Targets PARK2 to dysfunctional depolarized mitochondria through the phosphorylation of MFN2. Serine/threonine-protein kinase PINK1, mitochondrial BRPK PTEN-induced putative kinase protein 1 Gene name: PINK1
基因ID
65018
UniProt
Q9BXM7
途径
Autophagy
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