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CTLA4 抗体 (FITC)

CTLA4 适用: 大鼠 宿主: 小鼠 Monoclonal WKH 203 FITC
产品编号 ABIN161253
发货至: 中国
  • 抗原 See all CTLA4 抗体
    CTLA4 (Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4))
    适用
    • 91
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    大鼠
    宿主
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    小鼠
    克隆类型
    • 76
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    单克隆
    标记
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    This CTLA4 antibody is conjugated to FITC
    应用范围
    请咨询
    特异性
    Rat CD152
    免疫原
    Purified rCTLA-4hlg fusion protein . Fusion Partner: X63 Ag8.653 myeloma cells . Donor: BALB/c mice spleen cells
    克隆位点
    WKH 203
    亚型
    IgG1
    Top Product
    Discover our top product CTLA4 Primary Antibody
  • 限制
    仅限研究用
  • 状态
    Lyophilized
    浓度
    0.1 mg/ml
    缓冲液
    FITC conjugated Ig buffered in PBS, 0.02% NaN and EIA grade BSA as a stabilizing protein to bring total protein concentration to 4-5 mg/ml. (Purified from ascitic fluid via Protein G Chromatography).
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C
  • 抗原
    CTLA4 (Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4))
    别名
    CD152 (CTLA-4) (CTLA4 产品)
    别名
    CTLA-4 antibody, CTLA4 antibody, CD152 antibody, Cd152 antibody, Ctla-4 antibody, Ly-56 antibody, CD antibody, CELIAC3 antibody, GRD4 antibody, GSE antibody, IDDM12 antibody, sCTLA4 antibody, cytotoxic T-lymphocyte associated protein 4 antibody, cytotoxic T-lymphocyte-associated protein 4 antibody, CTLA4 antibody, Ctla4 antibody
    背景
    Anti-rat CD152 monoclonal antibody is specific for the cytotoxic T lymphocyte- associated protein 4 (CTLA-4), also called CD152. This antigen is known to be the receptor for B7 ligands (CD80 and CD86) present on antigen presenting cells. A subset of CD4 T cells expressing CD25 and CTLA-4 has been recognized as a potent suppressor cell popu- lation, counteracting autoimmunity and inflammation. These `regulatory' T cells (Treg) which produce the anti-inflammatory cytokine interleukin-10 (IL-10) but not IL-2, are able to suppress the proliferation of costimulated CD25- negative indicator cells. The capacity of these naturally occurring regulatory T cells to suppress autoimmunity and inflammation suggests that therapies which activate and expand this subset could become extremely effective treatments for these immunopathological disorders. This clone has been tested in flow cytometry. In rats, the constitutive expression of CTLA-4 at the level detectable by flow cytometry is restricted to the CD25+ subset of CD4 T cells and thymocytes.
    途径
    Cancer Immune Checkpoints
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