CD130/gp130 抗体
(23 references)Quick Overview for CD130/gp130 抗体 (ABIN1383685)
抗原
See all CD130/gp130 (IL6ST) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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特异性
- Recognises the Gp130, common subunit for IL-6, IL-11, OSM, LIF, CNTF, CT-1 receptors, a 130-140 kDa protein
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纯化方法
- Ion exchange chromatography
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过滤
- 0.22 μm filtered
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免疫原
- Natural soluble gp130,Myeloma X63/AG.8653 x Balb/c spleen cells
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亚型
- IgG1 kappa
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Biological Activity Comment
- Activates cells carrying gp130. Induces gp130 activation, Jak 1, Jak 2, Stat 1 and Stat 3 phosphorylation
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anti-Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) (IL6ST) (AA 392-566) antibody
IL6ST 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) (IL6ST) (AA 238-500) antibodyIL6ST 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) (IL6ST) (AA 73-231) antibodyIL6ST 适用: 人, 猴 WB, IHC, ELISA, FACS, ICC 宿主: 小鼠 Monoclonal 8D4D2 unconjugated
anti-Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) (IL6ST) (AA 26-323) antibodyIL6ST 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) (IL6ST) (AA 871-899), (C-Term) antibodyIL6ST 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB17993 unconjugated
anti-Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) (IL6ST) (pSer782) antibodyIL6ST 适用: 人, 大鼠 WB, ELISA, ICC, IF (p), IF (cc), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) (IL6ST) (AA 651-750) antibodyIL6ST 适用: 人, 小鼠, 大鼠 WB, ELISA, FACS, IF (p), IF (cc), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) (IL6ST) (AA 678-857) antibodyKO Validated IL6ST 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) (IL6ST) (AA 678-857) antibodyIL6ST 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) (IL6ST) antibodyIL6ST 适用: 人 WB, IHC, ELISA, FACS, IP, Func 宿主: 小鼠 Monoclonal B-P4 unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Phosphate-buffered saline. Sterile-filtered through 0.22 μm. Carrier and preservative free
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储存液
- Without preservative
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储存条件
- 4 °C
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储存方法
- Stable at +2-8°C for 12 months. For longer storage freeze aliquots.
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: "Inhibition of gp130 signaling in breast cancer blocks constitutive activation of Stat3 and inhibits in vivo malignancy." in: Cancer research, Vol. 64, Issue 19, pp. 6924-33, (2004) (PubMed).
: "Human cardiomyocyte hypertrophy induced in vitro by gp130 stimulation." in: Cardiovascular research, Vol. 59, Issue 1, pp. 78-85, (2003) (PubMed).
: "Long term association of the cytokine receptor gp130 and the Janus kinase Jak1 revealed by FRAP analysis." in: The Journal of biological chemistry, Vol. 278, Issue 40, pp. 39205-13, (2003) (PubMed).
: "gp130-linked signal transduction promotes the differentiation and maturation of dendritic cells." in: International immunology, Vol. 14, Issue 6, pp. 599-603, (2002) (PubMed).
: "Down-regulation of human CYP3A4 by the inflammatory signal interleukin-6: molecular mechanism and transcription factors involved." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 16, Issue 13, pp. 1799-801, (2002) (PubMed).
: "Separate functions for the two modules of the membrane-proximal cytokine binding domain of glycoprotein 190, the leukemia inhibitory factor low affinity receptor, in ligand binding and receptor activation." in: The Journal of biological chemistry, Vol. 277, Issue 16, pp. 13682-92, (2002) (PubMed).
: "Secretion of IL-6, IL-11 and LIF by human cardiomyocytes in primary culture." in: Cytokine, Vol. 18, Issue 4, pp. 199-205, (2002) (PubMed).
: "STAT3 is constitutively activated in Hodgkin cell lines." in: Blood, Vol. 98, Issue 3, pp. 762-70, (2001) (PubMed).
: "Ligand-specific utilization of the extracellular membrane-proximal region of the gp130-related signalling receptors." in: The Biochemical journal, Vol. 345 Pt 1, pp. 25-32, (2000) (PubMed).
: "Importance of the membrane-proximal extracellular domains for activation of the signal transducer glycoprotein 130." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 164, Issue 1, pp. 273-82, (2000) (PubMed).
: "Identification of a gp130 cytokine receptor critical site involved in oncostatin M response." in: The Journal of biological chemistry, Vol. 275, Issue 8, pp. 5648-56, (2000) (PubMed).
: "Agonist anti-gp130 transducer monoclonal antibodies are human myeloma cell survival and growth factors." in: Leukemia, Vol. 14, Issue 1, pp. 188-97, (2000) (PubMed).
: "Studies on the interleukin-6-type cytokine signal transducer gp130 reveal a novel mechanism of receptor activation by monoclonal antibodies." in: The Journal of biological chemistry, Vol. 275, Issue 7, pp. 4579-86, (2000) (PubMed).
: "Activation of the signal transducer glycoprotein 130 by both IL-6 and IL-11 requires two distinct binding epitopes." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 162, Issue 3, pp. 1480-7, (1999) (PubMed).
: "Receptor recognition sites of cytokines are organized as exchangeable modules. Transfer of the leukemia inhibitory factor receptor-binding site from ciliary neurotrophic factor to interleukin-6." in: The Journal of biological chemistry, Vol. 274, Issue 17, pp. 11859-67, (1999) (PubMed).
: "Internalization of the interleukin 6 signal transducer gp130 does not require activation of the Jak/STAT pathway." in: The Biochemical journal, Vol. 330 ( Pt 1), pp. 47-54, (1998) (PubMed).
: "The immunoglobulin-like module of gp130 is required for signaling by interleukin-6, but not by leukemia inhibitory factor." in: The Journal of biological chemistry, Vol. 273, Issue 35, pp. 22701-7, (1998) (PubMed).
: "A gp130 interleukin-6 transducer-dependent SCID model of human multiple myeloma." in: Blood, Vol. 91, Issue 12, pp. 4727-37, (1998) (PubMed).
: "Interleukin-6: structure-function relationships." in: Protein science : a publication of the Protein Society, Vol. 6, Issue 5, pp. 929-55, (1997) (PubMed).
: "Reconstitution of two isoforms of the human interleukin-11 receptor and comparison of their functional properties." in: FEBS letters, Vol. 407, Issue 2, pp. 141-7, (1997) (PubMed).
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: "Inhibition of gp130 signaling in breast cancer blocks constitutive activation of Stat3 and inhibits in vivo malignancy." in: Cancer research, Vol. 64, Issue 19, pp. 6924-33, (2004) (PubMed).
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- CD130/gp130 (IL6ST) (Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) (IL6ST))
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别名
- CD130
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背景
- Gp130
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分子量
- 130-140 kDa
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途径
- JAK/STAT Signaling, Cellular Glucan Metabolic Process, Autophagy, Smooth Muscle Cell Migration, Cancer Immune Checkpoints
抗原
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