CD130/gp130 抗体
(26 references)Quick Overview for CD130/gp130 抗体 (ABIN1383683)
抗原
See all CD130/gp130 (IL6ST) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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特异性
- Recognises the Gp130, common subunit for IL-6, IL-11, OSM, LIF, CNTF, CT-1 receptors, a 130-140 kDa protein
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纯化方法
- Ion exchange chromatography
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过滤
- 0.22 μm filtered
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免疫原
- Natural soluble gp130,Myeloma X63/AG.8653 x Balb/c spleen cells
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亚型
- IgG1 kappa
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Biological Activity Comment
- Inhibits IL-11 activity and binding to gp130, but not CNTF, LIF and OSM activities
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anti-Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) (IL6ST) (AA 392-566) antibody
IL6ST 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) (IL6ST) (AA 238-500) antibodyIL6ST 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) (IL6ST) (AA 73-231) antibodyIL6ST 适用: 人, 猴 WB, IHC, ELISA, FACS, ICC 宿主: 小鼠 Monoclonal 8D4D2 unconjugated
anti-Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) (IL6ST) (AA 26-323) antibodyIL6ST 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) (IL6ST) (AA 871-899), (C-Term) antibodyIL6ST 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB17993 unconjugated
anti-Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) (IL6ST) (pSer782) antibodyIL6ST 适用: 人, 大鼠 WB, ELISA, ICC, IF (p), IF (cc), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) (IL6ST) (AA 651-750) antibodyIL6ST 适用: 人, 小鼠, 大鼠 WB, ELISA, FACS, IF (p), IF (cc), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) (IL6ST) (AA 678-857) antibodyIL6ST 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) (IL6ST) (AA 678-857) antibodyKO Validated IL6ST 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) (IL6ST) (AA 23-122) antibodyIL6ST 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 4A4 unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Phosphate-buffered saline. Sterile-filtered through 0.22 μm. Carrier and preservative free
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储存液
- Without preservative
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储存条件
- 4 °C
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储存方法
- Stable at +2-8°C for 12 months. For longer storage freeze aliquots.
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: "N-linked glycosylation is essential for the stability but not the signaling function of the interleukin-6 signal transducer glycoprotein 130." in: The Journal of biological chemistry, Vol. 285, Issue 3, pp. 1781-9, (2010) (PubMed).
: "Unraveling viral interleukin-6 binding to gp130 and activation of STAT-signaling pathways independently of the interleukin-6 receptor." in: Journal of virology, Vol. 83, Issue 10, pp. 5117-26, (2009) (PubMed).
: "Structure-guided optimization of the interleukin-6 trans-signaling antagonist sgp130." in: The Journal of biological chemistry, Vol. 283, Issue 40, pp. 27200-7, (2008) (PubMed).
: "Dimerization of the cytokine receptors gp130 and LIFR analysed in single cells." in: Journal of cell science, Vol. 118, Issue Pt 21, pp. 5129-40, (2005) (PubMed).
: "Polarity and lipid raft association of the components of the ciliary neurotrophic factor receptor complex in Madin-Darby canine kidney cells." in: Journal of cell science, Vol. 117, Issue Pt 10, pp. 2063-75, (2004) (PubMed).
: "The cytokine receptor gp130 and its soluble form are under hormonal control in human endometrium and decidua." in: Molecular human reproduction, Vol. 10, Issue 7, pp. 495-504, (2004) (PubMed).
: "Inhibition of gp130 signaling in breast cancer blocks constitutive activation of Stat3 and inhibits in vivo malignancy." in: Cancer research, Vol. 64, Issue 19, pp. 6924-33, (2004) (PubMed).
: "Long term association of the cytokine receptor gp130 and the Janus kinase Jak1 revealed by FRAP analysis." in: The Journal of biological chemistry, Vol. 278, Issue 40, pp. 39205-13, (2003) (PubMed).
: "A functional role of the membrane-proximal extracellular domains of the signal transducer gp130 in heterodimerization with the leukemia inhibitory factor receptor." in: European journal of biochemistry / FEBS, Vol. 269, Issue 11, pp. 2716-26, (2002) (PubMed).
: "Interleukin-6-induced proliferation of pre-B cells mediated by receptor complexes lacking the SHP2/SOCS3 recruitment sites revisited." in: European journal of biochemistry / FEBS, Vol. 268, Issue 24, pp. 6401-7, (2001) (PubMed).
: "Receptor engagement by viral interleukin-6 encoded by Kaposi sarcoma-associated herpesvirus." in: Blood, Vol. 98, Issue 10, pp. 3042-9, (2001) (PubMed).
: "Importance of the membrane-proximal extracellular domains for activation of the signal transducer glycoprotein 130." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 164, Issue 1, pp. 273-82, (2000) (PubMed).
: "The cytoplasmic tyrosine motifs in full-length glycoprotein 130 have different roles in IL-6 signal transduction." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 164, Issue 2, pp. 848-54, (2000) (PubMed).
: "The inhibition of interleukin-6-dependent STAT activation by mitogen-activated protein kinases depends on tyrosine 759 in the cytoplasmic tail of glycoprotein 130." in: The Journal of biological chemistry, Vol. 275, Issue 25, pp. 18810-7, (2000) (PubMed).
: "SOCS3 exerts its inhibitory function on interleukin-6 signal transduction through the SHP2 recruitment site of gp130." in: The Journal of biological chemistry, Vol. 275, Issue 17, pp. 12848-56, (2000) (PubMed).
: "Signal transduction of IL-6, leukemia-inhibitory factor, and oncostatin M: structural receptor requirements for signal attenuation." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 165, Issue 5, pp. 2535-43, (2000) (PubMed).
: "Two different epitopes of the signal transducer gp130 sequentially cooperate on IL-6-induced receptor activation." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 165, Issue 12, pp. 7042-9, (2000) (PubMed).
: "Studies on the interleukin-6-type cytokine signal transducer gp130 reveal a novel mechanism of receptor activation by monoclonal antibodies." in: The Journal of biological chemistry, Vol. 275, Issue 7, pp. 4579-86, (2000) (PubMed).
: "Characterization of soluble gp130 released by melanoma cell lines: A polyvalent antagonist of cytokines from the interleukin 6 family." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 3, Issue 8, pp. 1443-51, (1999) (PubMed).
: "Activation of the signal transducer glycoprotein 130 by both IL-6 and IL-11 requires two distinct binding epitopes." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 162, Issue 3, pp. 1480-7, (1999) (PubMed).
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: "N-linked glycosylation is essential for the stability but not the signaling function of the interleukin-6 signal transducer glycoprotein 130." in: The Journal of biological chemistry, Vol. 285, Issue 3, pp. 1781-9, (2010) (PubMed).
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- CD130/gp130 (IL6ST) (Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) (IL6ST))
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别名
- CD130
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背景
- Gp130
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分子量
- 130-140 kDa
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途径
- JAK/STAT Signaling, Cellular Glucan Metabolic Process, Autophagy, Smooth Muscle Cell Migration, Cancer Immune Checkpoints
抗原
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