CD130/gp130 抗体
(18 references)Quick Overview for CD130/gp130 抗体 (ABIN1383678)
抗原
See all CD130/gp130 (IL6ST) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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特异性
- Recognises the Gp130, common subunit for IL-6, IL-11, OSM, LIF, CNTF, CT-1 receptors, a 130-140 kDa protein
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纯化方法
- Ion exchange chromatography
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过滤
- 0.22 μm filtered
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免疫原
- Natural soluble gp130,Myeloma X63/AG.8653 x Balb/c spleen cells
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亚型
- IgG2a, kappa
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Biological Activity Comment
- Inhibits IL-6, IL-11, CNTF, LIF and OSM activities
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anti-Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) (IL6ST) (AA 392-566) antibody
IL6ST 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) (IL6ST) (AA 238-500) antibodyIL6ST 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) (IL6ST) (AA 73-231) antibodyIL6ST 适用: 人, 猴 WB, IHC, ELISA, FACS, ICC 宿主: 小鼠 Monoclonal 8D4D2 unconjugated
anti-Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) (IL6ST) (AA 26-323) antibodyIL6ST 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) (IL6ST) (AA 871-899), (C-Term) antibodyIL6ST 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB17993 unconjugated
anti-Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) (IL6ST) (pSer782) antibodyIL6ST 适用: 人, 大鼠 WB, ELISA, ICC, IF (p), IF (cc), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) (IL6ST) (AA 651-750) antibodyIL6ST 适用: 人, 小鼠, 大鼠 WB, ELISA, FACS, IF (p), IF (cc), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) (IL6ST) antibodyIL6ST 适用: 人 WB, IHC, ELISA, FACS, IP, Func 宿主: 小鼠 Monoclonal B-P4 unconjugated
anti-Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) (IL6ST) (AA 678-857) antibodyIL6ST 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) (IL6ST) (AA 678-857) antibodyKO Validated IL6ST 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Phosphate-buffered saline. Sterile-filtered through 0.22 μm. Carrier and preservative free
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储存液
- Without preservative
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储存条件
- 4 °C
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储存方法
- Stable at +2-8°C for 12 months. For longer storage freeze aliquots.
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: "Akt signaling pathway: a target for radiosensitizing human malignant glioma." in: Neuro-oncology, Vol. 12, Issue 5, pp. 434-43, (2010) (PubMed).
: "N-linked glycosylation is essential for the stability but not the signaling function of the interleukin-6 signal transducer glycoprotein 130." in: The Journal of biological chemistry, Vol. 285, Issue 3, pp. 1781-9, (2010) (PubMed).
: "In vivo modulation of soluble \" IL-6 receptor synthesis and release in ESRD." in: Journal of the American Society of Nephrology : JASN, Vol. 16, Issue 4, pp. 1099-107, (2005) (PubMed).
: "Soluble mannose 6-phosphate/insulin-like growth factor II (IGF-II) receptor inhibits interleukin-6-type cytokine-dependent proliferation by neutralization of IGF-II." in: Endocrinology, Vol. 144, Issue 12, pp. 5381-9, (2003) (PubMed).
: "Down-regulation of human CYP3A4 by the inflammatory signal interleukin-6: molecular mechanism and transcription factors involved." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 16, Issue 13, pp. 1799-801, (2002) (PubMed).
: "Gp130 and ras mediated signaling in human plasma cell line INA-6: a cytokine-regulated tumor model for plasmacytoma." in: The hematology journal : the official journal of the European Haematology Association / EHA, Vol. 2, Issue 1, pp. 42-53, (2002) (PubMed).
: "STAT3 is constitutively activated in Hodgkin cell lines." in: Blood, Vol. 98, Issue 3, pp. 762-70, (2001) (PubMed).
: "Receptor engagement by viral interleukin-6 encoded by Kaposi sarcoma-associated herpesvirus." in: Blood, Vol. 98, Issue 10, pp. 3042-9, (2001) (PubMed).
: "Identification of a gp130 cytokine receptor critical site involved in oncostatin M response." in: The Journal of biological chemistry, Vol. 275, Issue 8, pp. 5648-56, (2000) (PubMed).
: "Agonist anti-gp130 transducer monoclonal antibodies are human myeloma cell survival and growth factors." in: Leukemia, Vol. 14, Issue 1, pp. 188-97, (2000) (PubMed).
: "Studies on the interleukin-6-type cytokine signal transducer gp130 reveal a novel mechanism of receptor activation by monoclonal antibodies." in: The Journal of biological chemistry, Vol. 275, Issue 7, pp. 4579-86, (2000) (PubMed).
: "Mannose 6-Phosphate/Insulin-like growth factor II receptor mediates internalization and degradation of leukemia inhibitory factor but not signal transduction." in: The Journal of biological chemistry, Vol. 274, Issue 35, pp. 24685-93, (1999) (PubMed).
: "Internalization of the interleukin 6 signal transducer gp130 does not require activation of the Jak/STAT pathway." in: The Biochemical journal, Vol. 330 ( Pt 1), pp. 47-54, (1998) (PubMed).
: "Reconstitution of two isoforms of the human interleukin-11 receptor and comparison of their functional properties." in: FEBS letters, Vol. 407, Issue 2, pp. 141-7, (1997) (PubMed).
: "Signaling of type II oncostatin M receptor." in: The Journal of biological chemistry, Vol. 272, Issue 25, pp. 15760-4, (1997) (PubMed).
: "Anti-gp130 transducer monoclonal antibodies specifically inhibiting ciliary neurotrophic factor, interleukin-6, interleukin-11, leukemia inhibitory factor or oncostatin M." in: Journal of immunological methods, Vol. 190, Issue 1, pp. 21-7, (1996) (PubMed).
: "Interleukin-6 family of cytokines induced activation of different functional sites expressed by gp130 transducing protein." in: The Journal of biological chemistry, Vol. 271, Issue 25, pp. 14764-72, (1996) (PubMed).
: "Interleukin-10 is a growth factor for human myeloma cells by induction of an oncostatin M autocrine loop." in: Blood, Vol. 88, Issue 10, pp. 3972-86, (1996) (PubMed).
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: "Akt signaling pathway: a target for radiosensitizing human malignant glioma." in: Neuro-oncology, Vol. 12, Issue 5, pp. 434-43, (2010) (PubMed).
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- CD130/gp130 (IL6ST) (Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) (IL6ST))
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别名
- CD130
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背景
- Gp130
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分子量
- 130-140 kDa
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途径
- JAK/STAT Signaling, Cellular Glucan Metabolic Process, Autophagy, Smooth Muscle Cell Migration, Cancer Immune Checkpoints
抗原
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