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- 抗原 See all SHC1 抗体
- SHC1 (SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1))
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抗原表位
- C-Term
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适用
- 人, 小鼠
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This SHC1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Frozen Sections) (IHC (fro))
- 特异性
- This antibody specifically recognizes the C-terminus of shc.
- 产品特性
- Synonyms: SHC-transforming protein 1, SHC-transforming protein A, SHC-transforming protein 3,SHCA, Src homology 2 domain-containing-transforming protein C1
- 纯化方法
- Subsequent thiophilic adsorption and size exclusion chromatography
- 组件
- incl. positive Control
- 免疫原
- Synthetic peptide conjugated to hemocyanin
- 克隆位点
- 11F6
- 亚型
- IgG1
- Top Product
- Discover our top product SHC1 Primary Antibody
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anti-SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1) (AA 171-280) antibody
SHC1 适用: 人 WB, ELISA, IF, IHC (p), PLA 宿主: 小鼠 Monoclonal 3F4 unconjugated
anti-SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1) (AA 385-495) antibodySHC1 适用: 人, 小鼠 WB, ELISA, ICC, FACS 宿主: 小鼠 Monoclonal 2F7C7 unconjugated
anti-SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1) (AA 536-564), (C-Term) antibodySHC1 适用: 人, 小鼠, 大鼠 WB, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1) (AA 424-440), (C-Term) antibodySHC1 适用: 人, 大鼠 WB, IHC (p), ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1) (C-Term) antibodySHC1 适用: 人, 小鼠, 大鼠 WB, IHC (p), ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1) (AA 272-559) antibodySHC1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1) antibodySHC1 适用: 人, 小鼠, 大鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1) (pTyr427) antibodySHC1 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1) (pTyr349) antibodySHC1 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1) (AA 171-280) antibodySHC1 适用: 人 WB, IHC, ELISA, IF, IHC (p), PLA 宿主: 小鼠 Monoclonal 3F4 unconjugated
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- 应用备注
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Western Blot: 1 μg/mL for HRPO/ECL detection. Recommended buffer: Casein/Tween 20 based blocking and blot incubation buffer. Recommended positive control: Cell lysate from untreated 3T3 cells. Immunocytochemistry. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - 限制
- 仅限研究用
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- 溶解方式
- Restore with 1 mL H2O (15 min, RT).
- 缓冲液
- 1 mLPBS / 0.09 % Na-azide / PEG and Sucrose
- 储存液
- Sodium azide
- 注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
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For long-term storage, freeze lyophilizate upon arrival (-20 °C). Upon reconstitution, aliquote and freeze in liquid nitrogen. Avoid repeated freezing and thawing.
Shelf life: one year from despatch. Thaw aliquots at 37 °C. Thawed aliquots may be stored at 4 °C up to 3 months. - 有效期
- 12 months
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- 抗原
- SHC1 (SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1))
- 别名
- SHC1 / SHC (SHC1 产品)
- 别名
- SHC1 antibody, SHC antibody, SHCA antibody, P66shc antibody, si:dkey-246i14.4 antibody, wu:fc10h03 antibody, shc antibody, p66shc antibody, Shc antibody, ShcA antibody, p66 antibody, SHC adaptor protein 1 antibody, Shc1p antibody, squalene--hopene cyclase antibody, SHC (Src homology 2 domain containing) transforming protein 1 antibody, SHC (Src homology 2 domain containing) transforming protein 1 L homeolog antibody, src homology 2 domain-containing transforming protein C1 antibody, SHC1 antibody, shc1 antibody, Shc1 antibody, shc1.L antibody
- 背景
- Mammalian cells can express three alternatively spliced isoforms of the shc adaptor protein: shc/p46, shc/p52 and shc/p66. shc/p66 contains a unique N-terminal protein domain. In addition to tyrosine phosphorylation of Tyr 239/240 and/or Tyr 317, shc/p66 is phosphorylated at serine 36, e.g. in response to EGF. Serine phosphorylation of shc/p66 impairs its ability to bind to the activated EGF receptor thus inhibiting EGF receptor downstream signalling pathways.Synonyms: SHC-transforming protein 1, SHC-transforming protein 3, SHC-transforming protein A, SHCA, Src homology 2 domain-containing-transforming protein C1
- 基因ID
- 6464
- UniProt
- P29353
- 途径
- RTK signaling, TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, ER-Nucleus Signaling, Signaling Events mediated by VEGFR1 and VEGFR2
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